摘要
目的探讨孕中期产前筛查血清三联指标的意义。方法回顾性分析9 612例孕中期孕妇血清AFP、β-hCG和E3检测结果,将检测数据和孕妇年龄、体重、孕周等输入软件中进行风险评估,高风险者采用羊水细胞染色体分析进一步确诊,其中NTD高风险者行多普勒超声确诊,随访妊娠结局。结果 9 612例孕妇中,高风险者占5.23%(503/9612)。459例高风险孕妇进行了产前诊断和跟踪随访,不良妊娠结局发生率6.54%(30/459);7936例低风险孕妇获随访,不良妊娠结局发生率为2.13%(169/7936)。两组比较有统计学意义(χ^2=36.28,P<0.01)。结论孕中期产前筛查检测血清AFP、β-HCG和E3,有助于不良妊娠结局的预测。
Objective To explore the significance of serum triple index for prenatal screening during the second trimester.Methods Retrospectively analyzed the serum AFP,β-hCG and E3 test results of 9 612 pregnant women in the second trimester of pregnancy.The test data and the age,weight,and gestational age of the pregnant women were input into the software for risk assessment.High-risk patients were further diagnosed by chromosome analysis of amniotic fluid cells.Among them,those with high risk of NTD were diagnosed with Doppler ultrasound,and the pregnancy outcome was followed up.Results Among 9612 pregnant women,5.23% were at high risk(503/9612).Prenatal diagnosis and follow-up were performed on 459 high-risk pregnant women.The incidence of adverse pregnancy outcome was 6.54%(30/459).7,936 low-risk pregnant women were followed up,and the incidence of adverse pregnancy outcome was 2.13%(169/7936).The comparison between the two groups was statistically significant (χ^2=36.28,P<0.01).ConclusionPrenatal screening for serum AFP,βHCG and E3 during the second trimester can help predict the outcome of adverse pregnancy.
作者
赵莹莹
高美华
ZHAO Ying-ying;GAO Mei-hua(Medical College of Qingdao University,Qingdao 266071,China)
出处
《山东医学高等专科学校学报》
2020年第1期41-43,共3页
Journal of Shandong Medical College
关键词
孕中期
血清三联指标
产前筛查
Second trimester
Serum triplet index
Prenatal screening
