摘要
目的：探讨孕中期母血游离β人绒毛膜促性腺激素（Freeβhuman chorionic gonadotropin,Freeβ-hCG）与甲胎蛋白（Alpha-fetoprotein,AFP）的测定在产前筛查中的应用。方法：回顾性分析萧山医院2009年10月-2012年9月38 639例孕妇临床资料,均采用半自动时间分辨荧光免疫分析法检测孕妇血清AFP、Freeβ-hCG水平,通过wallac软件评估胎儿患唐氏综合征（DS）、爱德华综合征（ES）、神经管缺陷（NTD）的风险,并随访分析产前诊断结果及妊娠结局。结果：38 639例孕妇中完成回访33 559例（86.85%）,高风险共994例（2.96%）,其中DS高风险838例,ES高风险18例,NTD高风险118例。产前诊断及追踪随访发现高风险异常44例（4.43%）,低风险异常304例,假阴性率为0.93%。结论：孕中期母血Freeβ-hCG、AFP检测结合孕妇年龄、体重、孕周、孕产史有利于发现高风险孕妇,结合产前诊断可提高胎儿异常检出率。
Objective： To explore the applications of serum free β-human chorionic gonadotropin（ β-hCG） and alpha fetoprotein（ AFP） detection during the second trimester of pregnancy. Methods： The clinical data of 38 639 pregnant women in Xiaoshan Hospital from October 2009 to September 2012 were analyzed retrospectively,the serum levels of AFP and free β- hCG were detected by semi- automatic time- resolved fluorescence immunoassay; wallac software was used to evaluate fetal risks of Down＇s syndrome（ DS）,Edward syndrome（ ES） and neural tube defect（ NTD）; the result of prenatal diagnosis and pregnancy outcome were followed up and analyzed. Results： Among 38 639 pregnant women,33 559 pregnant women（ 86. 85%） were followed up successfully,994 high risk pregnant women（ 2.96%） were found,including 838 DS high risk pregnant women,18 ES high risk pregnant women and 118 NTD high risk pregnant women. A total of 44 pregnant women（ 4. 43%） of high- risk abnormalities and 304 pregnant women of low- risk abnormalities were found by prenatal diagnosis and follow- up; the false negative rate was 0. 93%. Conclusion： Maternal serum free β- hCG and AFP detection during the second trimester of pregnancy combined with maternal age,body weight,gestational week and pregnant history are helpful to find high risk pregnant women,which can improve the detection rate of fetal abnormalities combining with prenatal diagnosis.
出处
《中国妇幼保健》
CAS
北大核心
2014年第16期2498-2500,共3页
Maternal and Child Health Care of China
关键词
产前筛查
出生缺陷
产前诊断
Prenatal screening Birth defect Prenatal diagnosis
