摘要
目的研究宽筋藤对小鼠抗疲劳、耐缺氧作用。方法给药组小鼠分别给予宽筋藤水提液进行14天灌胃预处理;对小鼠进行常压耐缺氧实验,观察小鼠耐缺氧的时间;采用力竭游泳实验,观察小鼠的游泳力竭时间;采用眼球取血,测血乳酸、血尿素氮含量;取肝脏,计算肝脏系数,观察小鼠的抗疲劳、耐缺氧的作用。结果与正常对照组比较,中剂量组、高剂量组能显著延长小鼠呼吸停止时间及游泳力竭时间(P<0.05或0.01);中剂量组、高剂量组对小鼠的肝脏指数有显著性影响(P<0.01);低剂量组、中剂量组、高剂量组可明显降低小鼠运动后的血清乳酸含量(P<0.05或0.01);中剂量组、高剂量组可降低小鼠运动后的血清尿素氮含量(P<0.05或0.01)。结论宽筋藤水提液具有抗疲劳、耐缺氧作用;该实验剂量下对小鼠肝脏可能有影响。
Objective To study the anti fatigue and anti hypoxia effects of Tinospora sinensis in mice.Methods Mice in the administration group were given the aqueous extract of tinospora sinensis by gavage for 14 days.The tests for hypoxia tolerance under normal pressure and exhaustive swimming were given to observe the time respectively.The blood taken from the eyeball was used to measure the content of blood lactate and blood urea nitrogen;the liver was taken to calculate the liver co-efficiency for its function on the anti fatigue and hypoxia tolerance.Results Compared with the normal control group,middle and high dose groups markedly prolonged the time of respiratory arrest and swimming exhaustion(P<0.05 or 0.01),lowered the content of serum urea nitrogen after exercise(P<0.05 or 0.01),and had significant effects on the liver index(P<0.01);all three groups greatly reduced the serum lactate content after exercise(P<0.05 or 0.01).Conclusion The aqueous extract of Tinospora sinensis has the effect of anti-fatigue and anti-hypoxia,whereas the doses may have an impact on mice’s liver.
作者
杨凤雯
韦秋菊
刘雪婷
周小苏
罗彩凤
黄永毅
YANG Fengwen;WEI Qiuju;LIU Xueting;ZHOU Xiaosu;LUO Caifeng;HUANG Yongyi(Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Functional Experimental Teaching Center,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)
出处
《右江医学》
2020年第1期23-27,共5页
Chinese Youjiang Medical Journal
基金
广西大学生创新创业训练计划项目(201810599052)
关键词
宽筋藤
小鼠
抗疲劳
耐缺氧
Tinospora sinensis
mice
fatigue resistance
hypoxia tolerance
