摘要
慢性阻塞性肺疾病(COPD)是一种慢性炎症性呼吸道疾病,其特征是持续气流受限和肺部炎症反应异常。气道内微生物是COPD恶化的主要原因,并且使气道中的炎症反应持续存在而促成COPD进展,这导致肺功能的进一步损害和巨大的医疗保健成本。近年来随着高通量测序技术的发展和运用,人类肺微生物组的研究逐渐成为热点。大量研究表明,COPD患者肺内存在明显不同的微生物群落,而且与COPD的疾病严重程度及恶化状态有关。肺微生物组学的研究有助于人们更全面地理解COPD患者肺内的微生态系统及其在该病恶化和进展中的作用。本文就肺微生物组在COPD中的研究进展作一综述,并探讨未来的研究前景。
Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory lung disorder which is characterized by persistent airflow limitation and an abnormal inflammatory response of the lung. Bacteria and viruses are a major cause of COPD exacerbations and may contribute to COPD progression by perpetuating the inflammatory response in the airways, which leads to further impairment of lung function and enormous health care costs. In recent years, with the development and application of high-throughput sequencing technology, the research on human lung microbiome has gradually become a hot spot. A great quantity of studies have shown that there is a distinct microbial community in the lungs of patients with COPD, and they are related to the severity and deterioration of COPD. Research on lung microbiome provides a more comprehensive understanding of the microecological system in the lungs of patients with COPD and its role in the exacerbation and progression of the disease. The aim of the article is to review the progress in research on lung microbiome in chronic obstructive pulmonary disease and explore future research prospects.
作者
李经历
刘玲静
董年
胡依然
陈成水
LI Jingli;LIU Lingjing;DONG Nian;HU Yiran;CHEN Chengshni(Department of Respiratory and Critical Cure Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)
出处
《中国微生态学杂志》
CAS
CSCD
2019年第12期1460-1464,共5页
Chinese Journal of Microecology
基金
国家重点研发项目(2016YFC130400)
关键词
慢性阻塞性肺疾病
微生物组
急性加重
Chronic obstructive pulmonary disease
Microbiome
Acute exacerbation
