摘要
目的探讨黄芪建中汤联合合募配穴灸法辅助治疗脾胃虚寒型幽门螺杆菌(H.pylori)阳性慢性萎缩性胃炎疗效及对患者炎性因子和胃蛋白酶原的影响。方法选取2015年5月—2018年5月广东省中西医结合医院收治的脾胃虚寒型H.pylori阳性慢性萎缩性胃炎患者137例,采用随机数字表法将患者分为对照组68例和研究组69例。对照组予以四联根除H.pylori治疗,研究组在对照组治疗基础上给予黄芪建中汤联合合募配穴灸法治疗,2组均治疗2周。观察2组患者治疗前后中医症状积分及炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]、胃蛋白酶原[胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ比值]水平变化,评价2组临床疗效,计算H.pylori根除率并记录治疗期间不良反应发生情况。结果2组治疗后胃痛、喜暖喜按、便溏、手足不温、乏力积分和血清IL-6、TNF-α、hs-CRP、PGⅡ水平均明显降低(P均<0.05),且研究组均明显低于对照组(P均<0.05);2组治疗后血清PGⅠ、PGⅠ/PGⅡ比值均明显升高(P均<0.05),且研究组均明显高于对照组(P均<0.05)。研究组治疗后临床总有效率为92.75%(64/69)、H.pylori根除率为95.65%(66/69),对照组治疗后临床总有效率为73.53%(38/68)、H.pylori根除率为80.88%(55/68),研究组治疗总有效率和H.pylori根除率均明显高于对照组(P均<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论黄芪建中汤联合合募配穴灸法辅助治疗脾胃虚寒型H.pylori阳性慢性萎缩性胃炎患者临床效果更好,H.pylori根除率更高,且可明显减轻炎症反应,调节胃蛋白酶原水平,且不增加不良反应。
Objective It is to explore the effects of Huangqi Jianzhong Decoction combined with moxibustion of matching of he-sea point and front Mu point on H.pylori(Hp)positive chronic atrophic gastritis(CAG)of type of spleen and stomach deficiency-cold and its effect on inflammatory factors and pepsinogen.Methods 137 cases of patients with Hp-positive CAG of type of spleen-stomach deficiency-cold who were treated from Guangdong Hospital of Integrated Chinese and Western Medicine from May 2015 to May 2018 were selected and randomly divided into control group(n=68)and study group(n=69).The control group was treated with quadruple eradication of H.pylori.The study group was treated with Huangqi Jianzhong Decoction combined with moxibustion of matching of he-sea point and front Mu point based on the treatment of the control group.Both groups were treated for 2 weeks.The changes of the TCM symptom scores and levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)],pepsinogen[pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),and PGⅠ/PGⅡratio]before and after treatment were observed in the two groups,the clinical efficacy was evaluated,Hp eradication rate was calculated,and adverse reactions during the treatment were recorded.Results After treatment,the scores of symptoms such as stomachache,comfort with warm and pressing,loose stool,unwarm hand and foot and fatigue and the levels of IL-6,TNF-α,hs-CRP,PGⅡwere decreased(P<0.05),while the level of PGⅠand PGⅠ/PGⅡratio were significantly increased in both groups(P<0.05),and the decrease and increase of these indexes were more significant in the study group than those in the control group(P<0.05).The total effective rate of the study group was 92.75%(64/69),which was higher than 73.53%(38/68)of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The eradication rate of HP in the study group was significantly higher than that in the control group(P<0.05).Conclusion Huangqi Jianzhong Decoction combined with moxibustion of matching of he-sea point and front Mu point has a better clinical effect and higher eradication rate of HP in patients with Hp-positive CAG of type of spleen-stomach deficiency-cold,it can significantly relieve inflammation and regulate pepsinogen levels without increasing adverse reactions.
作者
姚民武
徐兰
黄光鸿
YAO Minwu;XU Lan;HUANG Guanghong(Guangdong Hospital of Integrated Chinese and Western Medicine,Foshan 528000,Guangdong,China;Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong,China)
出处
《现代中西医结合杂志》
CAS
2020年第2期124-128,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省中医药局科研项目(20162246)
关键词
黄芪建中汤
合募配穴灸法
脾胃虚寒
幽门螺杆菌
慢性萎缩性胃炎
炎性因子
胃蛋白酶原
Huangqi Jianzhong Decoction
moxibustion of matching of he-sea point and front Mu point
spleen-stomach deficiency and cold
Helicobacter pylori
chronic atrophic gastritis
inflammatory factors
pepsinogen
