摘要
目的探讨6-11岁儿童警觉性注意发展的事件相关电位(event-related potential,ERP)特征。方法6~11岁学龄期儿童共144人,按年龄分组并进行持续性操作测试(continuous performance test,CPT)-AX(Go/Nogo)任务,对各年龄组儿童的行为学和额区cue/uncue-P3、CNV的潜伏期、波幅进行分析比较。结果(1)行为学比较,6岁组、7岁组、8岁组、10岁组,11岁组各年龄组正确数[35(31,38)个,37(34,38.25)个,37(34.75,39)个,38(35,39.25)个,39(37.25,40)个,39(39,40)个],正确反应时间[(566.88±86.63)ms,(530.10±83.40)ms,(509.17±8&99)ms,(488.31±76.23)ms,(463.45±75.78)ms,(417.24±75.78)ms]之间的差异均有统计学意义(£=44.512,11.155,均P<0.01);(2)Fz导联的ERP特征:①cue-CNV、uncue-CNV比较:6岁组[(-8.54±4.56)uV,(-10.13±6.36)uV],7岁组[(-9.20±5.34)uV,(-11.53±4.29)uV],8岁组[(-8.37±4.78)uV,(-11.35±6.38)uV],cue-CNV波幅均低于uncue-CNV波幅,差异有统计学意义(均P<0.05);9岁组[(689.25±268.22)ms,(826.13±174.62)ms],cue-CNV潜伏期较uncue-CNV潜伏期缩短,差异有统计学意义(P<0.05);②cue-P3、uncue-P3比较:6岁组[(4.29±4.11)uV,(7.45±3,83)uV],7岁组[(4.47±4,71)uV,(5.82±4.40)uV],8岁组[(3.76±3.39)uV,(6.24±4.91)uV],9岁组[(4.27±3.57)u,(5.93±3.08)uV],n岁组[(4.24±4.66)uV,(6.13±4.42)uV],cue-P3波幅均低于uncue-P3波幅,差异有统计学意义(均P<0.05);③各年龄组纵向比较:9岁组、11岁组cue-CNV潜伏期缩短,差异有统计学意义(P<0.05),10岁组的cue-CNV和cue-P3的波幅均较其他年龄组增高,差异有统计学意义(P<0.05)。结论随年龄增长,学龄期儿童CPT任务绩效逐龄提高;9~10岁儿童大脑警觉性注意认知网络和心理预测能力得到高速发展,可能与额叶皮质的成熟化发育有关。
ObjectuVe To explore the characteristics of event-related potential(ERP)in the development of alert attention of children aged 6-11 years old.Methods A total of 144 children aged 6-11 years old were enrolled in a continuous performance test(CPT,Go/Nogo stimulus task).The latency and amplitude of frontal region cue/uncue-P3 and CNV were analyzed and compared in all age groups.Results(1)Behavioral comparison among different age groups:correct number(35(31,38),37(34,38.25),37(34.75,39),38(35,39.25),39(37.25,40),39(39,40)).correct reaction time((566.88±86.63)ms,(530.10±83.40)ms,(509.17±88.99)ms,(488.31±76.23)ms,(463.45±75.78)ms,(417.24±75.78)ms),the differences were statistically significant(P<0.01).(2)Fz lead ERP characteristics:(I)Comparison of cue CNV and uncue-CNV:6-year-old group((一&54±4.56)uV qs(-10.13±6.36))uV),7-year-old group((-9.20±5.34))uV vs(-11.53±4.29)uV),8-year-old group((-8.37±4.78)uV vs(-11.35±6.38)uV)in amplitude and 9-year-old group((689.25±268.22)ms vs(826.13±174.62)ms)in latency were significantly different(P<0.05).②Comparison of cue-P3 and uncue-P3:6-year-old group((4.29±4.11)uV vs(7.45±3.83)uV),7-year-old group((4.47±4.71)uV vs(5.82±4.40)uV),8-year-old group((3.76±3.39)uV vs(6.24±4.91)uV),9-year-old group((4.27±3.57)uV vs(5.93±3.08)uV),H-year-old group((4.24±4.66)uV vs(6.13±4.42)uV)in amplitude were significantly different(P<0.05).③Longitudinal comparison among age groups:the latency of cue・CNV in 9-year-old group and 11-year-old group were shorter,and the difference was significant(P<0.05).The amplitudes of cue-CNV and cue-P3 in 10-year-old group were shorter than those in other age groups(P<0.05).Conclusion With the increase of age,the reaction time of school-age children shortened and the correct rate improved.The age of 9-10 may be the high・speed period of the development for brain network on vigilant attention and psychological prediction which may be related to the maturation and development of frontal cortex.
作者
廖丽娜
易阳
王超群
赵方乔
董毓
吴婷
Liao Lina;Yi Yang;Wang Chaoqun;Zhao Fangqiao;Dong Yu;Wu Ting(Department of Neurology,Affiliated Changzhou Children's Hospital of Nantong University,Changzhou 213000,China;Department of Respiration,Affiliated Changzhou Children s Hospital of Nantong University,Changzhou 213000,China;Children s Health Research Center,Affiliated Changzhou Children Hospital of Nantong University,Changzhou 213000,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2019年第11期1005-1009,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
常州市科技支撑计划(社会发展)项目(CE20185046)。
关键词
事件相关电位
学龄期儿童
警觉性注意
Event related potential
School-age children
Vigilant attention
