摘要
目的:观察艾灸背俞穴联合盐酸羟考酮缓释片对癌痛患者的镇痛作用。方法:采取随机对照的临床研究模型,纳入病例随机分成两组,对照组给予口服盐酸羟考酮缓释片治疗,观察组在对照组基础上给予艾灸背俞穴,两组疗程均为6 d。采用数字化评估表法(NRS)进行疼痛定量评估,以疼痛缓解率(PAR)评估疼痛改善效率,并于第7天采血清样本,检测IL-6及TNF-α水平。结果:两组治疗后各时段NRS评分均较治疗前显著下降(P均<0.05),观察组治疗后NRS评分均优于对照组(P均<0.05);两组治疗后观察组PAR优于对照组(P<0.05);两组治疗后血清TNF-α水平均较治疗前显著降低(P<0.05)且观察组优于对照组(P<0.05);对照组治疗后血清IL-6水平无明显改变(P>0.05),观察组治疗后血清IL-6水平较治疗前显著降低(P<0.05)。结论:艾灸背俞穴可对盐酸羟考酮缓释片的止痛效果有显著协同作用,初步证实该作用与炎症反应因子IL-6及TNF-α降低有关。
Objection:To compare therapeutic effects of analgesia induced by Back-Shu point moxibustion plus oral oxycodone tablets.Methods:Randomized controlled trial(RCT)research was designed in this study.The observation groups were treated with Back-Shu point moxibustion plus oxycodone,and the controls with oxycodone only.Course of the treatment was 6 days.Pain intensity was assessed by numerical rating scale(NRS);and pain relief rate(PAR)was used to assessing analgesia improvement efficiency.On 7th day,serum IL-6 and TNF-αwere detected by ELISA.Result:This study showed that NRS scores in both groups were decreased(all P<0.05).,and the NRS scores in the observation groups were better than that in the control groups(all P<0.05).And PAR of the observation group was better than that of the control group after treatment(P<0.05).Serum TNF-αwhich after treatment was significantly lower than that before treatment in both groups(P<0.05),and it was more significantly in observation groups(P<0.05).There was no significant changed in serum IL-6 level in the control groups(P>0.05);while the serum IL-6 was obviously diminished in the observation groups(P<0.05).Conclusion:Moxibustion at Back-Shu point had a significant synergistic ability on the analgesic effect of oral oxycodone tablets.This effect has been preliminarily confirmed to be related to the reduction of inflammatory response factors IL-6 and TNF-α.
作者
陈军
乔海法
李静
刘奇
Karataye Va Kymba
CHEN Jun;QIAO Haifa;LI Jing(Department of Acupuncture and Massage,Shaanxi University of Chinese Medicine,Xianyang 712046)
出处
《陕西中医》
2020年第1期105-107,共3页
Shaanxi Journal of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81704186)
