摘要
目的:探讨验方黄芪汤内服治疗溃脓期肺痈的临床疗效及其作用机制。方法:采用随机分组法将病例各分为治疗组(20例)与对照组(20例),治疗组用黄芪汤,用法:将药煎取400 ml,分早中晚饭后温服,1周为1个疗程,连用1月;对照组西医西药治疗方案选择单用足量敏感抗生素静滴,每天两次,连用1月;1月后复查X线胸片、胸部CT或MRI、支气管镜检查、痰或血培养、血常规等指标。将搜集的资料进行统计学处理。结果:治疗组能明显改善咳嗽、咳痰、胸痛、高热、畏寒、心悸、气短、纳差、乏力等全部证候(P<0.05),总有效率为95.00%,对照组能改善咳嗽、咳痰、胸痛、高热、畏寒等证候(P<0.05),总有效率为70.00%,两组治疗后在咳嗽、咳痰、胸痛、畏寒、纳差、乏力等证候评分上组间比较差异具有统计学意义(P<0.05),治疗组优于对照组。影像学指标,两组治疗后均能明显改善X线胸片、胸部CT及MRI等影像学指标(P<0.05),组间比较差异具有统计学意义(P<0.05);对于支气管镜像,两组患者治疗后都能降低支气管黏膜损害程度、炎症程度,提高管壁运动状态,组间比较差异具有统计学意义(P<0.05),治疗组优于对照组(P<0.05);两组患者管腔狭窄程度积分治疗前后及两组治疗后比较差异无统计学意义(P>0.05)。结论:黄芪汤可明显减轻溃脓期肺痈的临床症状及改善相应实验室检查指标。
Objective:To investigate the clinical efficacy and mechanism of Huangqi decoction in the treatment of pulmonary carbuncle in ulcerative stage.Methods:The cases were randomly divided into treatment group(20 cases)and control group(20 cases).The treatment group was treated with Huangqi decoction.Usage:decoct 400 ml of medicine and took it warm after breakfast,lunch and dinner,one week as a course of treatment,for one month.The control group was treated with western medicine by intravenous drip of sufficiently sensitive antibiotics,twice a day,for one month.Chest X-ray,chest CT or MRI,bronchoscopy,sputum or blood culture,blood routine and other indicators were re-examined after 1 month.The collected data were processed by statistics.Results:The treatment group could obviously improve all the symptoms of cough,sputum,chest pain,high fever,chills,palpitations,shortness of breath,poor appetite and fatigue(P<0.05).The total effective rate was 95.00%.The control group could improve the symptoms of cough,sputum,chest pain,high fever and chills(P<0.05).The total effective rate was 70.00%.After treatment,cough,palpitation,shortness of breath,poor appetite and fatigue were improved in both groups.There were significant differences in the scores of cough,chest pain,chills,poor appetite and fatigue between the two groups(P<0.05).The treatment group was better than the control group.For imaging indicators,the treatment group and the control group is a significant difference between the two groups(P<0.05);for bronchoscopy,the two groups can significantly improve X-ray chest film,chest CT and MR imaging indicators(P<0.05),can reduce the degree of bronchial mucosal damage and inflammation after treatment.There was significant difference between the two groups in improving wall motion(P<0.05),and the treatment group was better than the control group(P<0.05);There was no significant difference in the degree of lumen stenosis between the two groups before and after treatment(P>0.05).Conclusion:Huangqi decoction can obviously relieve the clinical symptoms of pulmonary carbuncle in purulent ulcer stage and improve the corresponding laboratory examination indicators,which is worthy of clinical application.
作者
彭勇
何江
周棉勇
PENG Yong;HE Jiang;ZHOU Mianyong(Department of Scientific Research and Teaching,Second Affiliated Hospital of Qiannan College of Ethnic Medicine,Duyun 558000)
出处
《陕西中医》
2020年第1期66-69,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
黔南民族医学高等专科学校校内科研基金项目(QNYZ201741)
关键词
溃脓期
肺痈
黄芪汤
经验方
临床观察
中医临床研究
Purulent ulcer
Lung carbuncle
Huangqi decoction
Experience prescription
Clinical observation
Clinical research of traditional chinese medicine
