摘要
目的:研究清金抗扩饮对支气管扩张症模型的作用,探讨清金抗扩饮的疗效机理。方法:建立SD大鼠支扩模型,中药组方清金抗扩饮治疗后,观察肺组织病理学特点,肺组织基质金属蛋白酶-9(MMP-9)及其组织抑制物(TIMP-1)水平的变化,探讨它们在支扩发病中的作用及清金抗扩饮对其的干预作用。结果:清金抗扩饮能显著抑制支扩大鼠肺组织MMP-9的水平,同时升高TIMP-1水平,及改善气道扩张的程度。结论:清金抗扩饮对支气管扩张症有明显治疗作用,该作用可能是通过抑制肺组织MMP-9的表达,促进TIMP-1的表达实现的。
Objective：To study the effects of Qingjinkangkuoyin on MMP-9 and TIMP-1 in Rats with bronchiectasis.Methods：Models were established by intrabronchially injecting with pseudomonas aeruginosa,and divided into 5 groups by random number table： the QJKKY high dose treatment group（given high dose of QJKKY into stomach）,the QJKKY low dose treatment group（given low dose of QJKKY）,the levofloxacin group（given levofloxacin）,the model group（given normal saline）,the normal contrast group（given normal saline）.After 2 weeks of treatment,the histopathology and the levels of MMP-9 and TIMP-1 in Rats＇ lung tissue were detected.Results：Qingjinkangkuoyin could alleviate pathological damage on lung,and decrease MMP-9 expression,improve TIMP-1 expression in rats＇ lung tissue.Conclusion：Qingjinkangkuoyin could cure bronchiectasis,maybe through decreasing MMP-9 expression,and improving TIMP-1 expression in lung tissue.
出处
《中华中医药学刊》
CAS
2013年第5期1079-1081,I0006,I0007,共5页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局资助项目(2009CB015)
