摘要
目的探究参芪健胃颗粒对脾胃虚寒证慢性萎缩性胃炎患者的胃肠激素及氧化应激状况的影响。方法选取2017年12月至2018年12月我院接收的80例脾胃虚寒证慢性萎缩性胃炎患者进行研究。按照随机数表法,将其分成2组。对照组采用西药治疗,观察组在对照组基础上服用参芪健胃颗粒。治疗2个月后,比较2组患者的临床治疗效果和中医证候评分,分析2组患者治疗前后的胃肠激素水平,检测指标包括胃动素、胃泌素、内皮素(ET)、表皮生长因子(EGF)和降钙素基因相关肽(CGRP),同时比较分析2组患者氧化应激指标的变化情况,检测超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH?鄄Px)、丙二醛。结果治疗3个月后,观察组临床疗效(92%)显著高于对照组(75%),差异有统计学意义(χ^2=4.501,P=0.034)。2组患者治疗前食少纳呆、倦怠乏力、胃脘胀满和胃脘疼痛评分的比较差异无统计学意义(P>0.05);治疗后食少纳呆、倦怠乏力、胃脘胀满和胃脘疼痛评分均明显降低,且观察组患者各项评分均显著低于对照组患者,差异具有统计学意义(P<0.05)。2组患者治疗前胃肠激素含量的比较差异无统计学意义(P>0.05);治疗后ET和EGF含量明显降低,胃动素、胃泌素、CGRP明显升高,且观察组患者变化更加显著,差异具有统计学意义(P<0.05)。2组患者治疗前氧化应激指标的比较差异无统计学意义(P>0.05);治疗后丙二醛含量明显降低,SOD和GSH?鄄Px明显升高,且观察组患者改善程度更显著,差异具有统计学意义(P<0.05)。结论应用参芪健胃颗粒治疗脾胃虚寒证慢性萎缩性胃炎可显著提高疗效,降低中医症候积分,改善患者胃肠激素水平和氧化应激状况,临床应用价值较高。
Objective To investigate the effect of Shenqi Jianwei granule on gastrointestinal hormones and oxidative stress in patients with chronic atrophic gastritis of spleen-stomach deficiency and cold syndrome.Methods Eighty patients with chronic atrophic gastritis of spleen-stomach deficiency and cold syndrome admitted to our hospital between December 2017 and December 2018 were included in the study.All patients were randomly divided into two groups.The control group was treated with Western medicine,and the study group was treated with Shenqi Jianwei granule.The clinical efficacy and TCM syndrome scores in the two groups at 2 months after the treatment were compared.The levels of gastrointestinal hormones at baseline and after treatment were examined,including motilin,gastrin,endothelin(ET),epidermal growth factor(EGF)and calcitonin gene-related peptide(CGRP).At the same time,the changes of oxidative stress indicators in the two groups were compared and analyzed,including superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA).Results At 3 months after the treatment,the clinical efficacy in the study group was significantly higher than that in the control group(92%vs 75%),with statistically significant difference(χ^2=4.501,P=0.034).There were no significant differences in the scores of diet deficiency,fatigue,epigastric fullness and epigastric pain between the two groups at the baseline(all P>0.05).After the treatment,the scores of diet deficiency,fatigue,epigastric fullness and epigastric pain significantly decreased,and the scores in the study group were significantly lower than those in the control group,with statistically significant differences(all P<0.05).There were no significant differences in the levels of gastrointestinal hormones between the two groups at the baseline(all P>0.05).After the treatment,the levels of ET and EGF decreased significantly,whereas the levels of motilin,gastrin and CGRP increased significantly,and the changes in the study group were more significant,with statistically significant differences(all P<0.05).There was no significant difference in oxidative stress index be-tween the two groups at the baseline(P>0.05).After the treatment,the MDA level decreased significantly,whereas the levels of SOD and GSH-Px increased significantly,and the improvement in the study group was more significant,with statistically significant differences(all P<0.05).Conclusion Using Shenqi JianJianwei granule in the treatment of chronic atrophic gastritis of spleen-stomach deficiency and cold syndrome may significantly improve the curative effect,reduce the TCM syndrome scores,and improve the levels of gastrointestinal hormones and oxidative stress,and therefore is worthwhile of widespread use in clinical practices.
作者
陈稀烦
骆瑛
张丹
Chen Xifan;Luo Ying;Zhang Dan(Department of Pharmacy,Hangzhou Geriatric Hospital,Zhejiang 310022,China)
出处
《中国药物与临床》
CAS
2020年第1期1-5,共5页
Chinese Remedies & Clinics
基金
浙江省医药卫生科技项目(2015KYB056)。
关键词
胃炎
萎缩性
参芪健胃颗粒
胃肠激素类
氧化性应激
Gastritis,atrophic
Shenqi Jianwei granule
Gastrointestinal hormones
Oxidative stress
