摘要
目的探讨阿莫西林联合铋剂对慢性萎缩性胃炎患者血清胃泌素-17及胃蛋白酶原水平的影响。方法收集收治的慢性萎缩性胃炎患者56例,随机分为对照组和实验组,每组各28例,在常规治疗基础上,对照组患者给予阿莫西林治疗,实验组患者在对照组基础上给予铋剂治疗,治疗结束后,对所有患者的血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平进行检测。结果治疗后,与对照组比较,实验组患者的血清G-17水平较高,差异具有统计学意义(P<0.05);实验组患者的血清PGⅠ、PGⅡ水平较高(P<0.05)。结论阿莫西林联合铋剂能够显著提高萎缩性胃炎患者血清G-17、PGⅠ水平,改善患者病情,对临床有指导意义。
Objective To analysis the effect of amoxicillin combined with bismuth on serum gastrin-17 and pepsinogen in patients with chronic atrophic gastritis. Methods 56 patients who were diagnosed with chronic atrophic gastritis were randomly divided into experimental group and control group,28 cases in each group. On the basis of conventional treatment,patients in the control group received amoxicillin therapy,patients in the experimental group were treated with bismuth on the basis of the control group treatment,after the treatment,the serum levels of pectin on serum gastrin-17（ G-17）,pepsinogenⅠ（ PGⅠ） and pepsinogenⅡ（ PGⅡ） were detected in all patients. Results After treatment,compared with control group,the serum level of G-17 was higher in the experimental group,and the difference was statistically significant（ P〈0. 05）; the serum level of PGⅠ was higher in the experimental group（ P〈0. 05）. Conclusion The amoxicillin combined with bismuth can significantly increase the serum level of G-17,PGⅠ in patients with chronic atrophic gastritis,improve the condition of patients,and have a guiding significance for clinica.
出处
《中国生化药物杂志》
CAS
2016年第3期64-66,共3页
Chinese Journal of Biochemical Pharmaceutics
