摘要
肌红蛋白(myoglobin,Mb)是一种小分子蛋白,由珠蛋白与正铁血红素结合而成。它能可逆地与氧结合,在肌细胞内起着转运和贮存氧的作用。临床多种因素可引起骨骼肌和心肌受损,细胞膜完整性改变,肌细胞内容物进入细胞外液及循环系统,致使血清肌红蛋白水平升高。此外,动态监测血清肌红蛋白含量变化,可预测临床多种疾病的严重程度及预后。本文就上述内容的进展作一综述。
Myoglobin(Mb)is a kind of small molecular protein integrated by globin and protoheme. It can be combined with oxygen reversibly and plays a key role in transporting and storing oxygen in muscle cells. A variety of clinical factors can cause damage to skeletal muscle and myocardium,change the cell membrane integrity,and make the contents of muscle cells to enter the extracellular fluid and circulatory system,resulting in increased serum myoglobin levels. In addition,dynamic monitoring of changes in serum myoglobin contents can predict the severity and prognosis of various clinical diseases. Here,we intend to make a review of the progress of the above contents.
作者
王延庆
韩玉珍
黄立锋
WANG Yanqing;HAN Yuzhen;HUANG Lifeng(Department of Surgical Intensive Care Unit,Beijing Chaoyang Hospital Affiliated to Capi⁃tal Medical University,Beijing 100020,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第24期3859-3863,共5页
The Journal of Practical Medicine
基金
国家自然科学基金资助项目(编号：81372042)
北京市属医院科研培育计划项目(编号：PX2019010)
北京朝阳医院“1351人才培养计划-朝阳新星”资助项目(编号：CYXX-2017-16)
关键词
肌红蛋白
免疫
预后
myoglobin
immune
prognosis
