摘要
目的观察不孕症患者中不同TSH水平对体外受精/卵泡浆内单精子注射-胚胎移植(in vitro fertilization/follicle intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)促排卵结局及妊娠结局的影响。方法回顾性分析太原市中心医院生殖中心2018年1月至2019年6月186例不孕患者不同TSH水平下行IVF/ICSI-ET助孕治疗的结局,分为A组(TSH<2.5 mU/L)、B组(2.5 mU/L≤TSH≤4 mU/L)均93例,记录并比较两组患者的一般情况、超促排卵治疗情况及妊娠结局。结果两组患者一般资料、促性腺激素(Gn)(总量/使用时间)、注射人绒毛膜促性腺激素日(E2/LH/P)、取卵日E2、获卵数、卵裂总数差异无统计学意义(P>0.05);正常受精率、晚期卵裂率、优质胚胎率、OHSS发生率及累计种植率、累计临床妊娠率、累计流产率差异均有统计学意义(P<0.05)。结论TSH<2.5 mU/L组患者可获得更高的正常受精率、优质胚胎率、累计种植率、累计临床妊娠率及较低的晚期卵裂率和累计流产率,并且OHSS发生率降低。
Objective To observe the effect of TSH levels on ovulation induction and pregnancy outcome of IVF/ICSI-ET IN infertility patients. Methods Retrospective analysis was performed on the outcomes of IVF/ICSIET assisted pregnancy treatment in the reproductive center of Taiyuan central hospital from January 2018 to June2019 in 186 infertile patients with different TSH levels,divided into group A(TSH < 2.5 mu/L)and group B(2.5 mu/L≤TSH≤4 mu/L)with 93 cases,and the general situation of the patients in the two groups,super-ovulation induction treatment and pregnancy outcome were recorded and compared. Results There were no significant differences in general information,gonadotropin(Gn)(total amount/time of use),HCG injection day(E2/LH/P),egg retrieval day(E2/LH/P),number of eggs obtained and total number of cleavage between the two groups(P >0.05). There were statistically significant differences in normal fertilization rate,late cleavage rate,high-quality embryo rate,OHSS incidence rate,cumulative implantation rate,cumulative clinical pregnancy rate,and cumulative abortion rate(P < 0.05). Conclusion TSH < 2.5 mU/L group patients can obtain higher normal fertilization rate,high quality embryo rate,accumulative implantation rate,accumulative clinical pregnancy rate,and lower late cleavage rate and accumulative abortion rate,accompanied with the reduced incidence of OHSS.
作者
彭超男
张晓敏
杨贵芳
王云燕
杨晓丽
李淑珍
PENG Chaonan;ZHANG Xiaomin;YANG Guifang;WANG Yunyan;YANG Xiaoli;LI Shuzhen(Departmen of Epidemiology,School of Public Health,Shanxi Medical University,Taiyuan 030001,China)
出处
《实用医学杂志》
CAS
北大核心
2019年第24期3769-3772,3777,共5页
The Journal of Practical Medicine
基金
国家自然科学基金(编号：81471478)
关键词
体外受精/卵细胞质内单精子注射-胚胎移植
促甲状腺激素
促排卵
妊娠
in vitro fertilization/follicle intracytoplasmic sperm injection-embryo transfer
thyroid stimulating hormone
stimulate ovulation
pregnancy
