摘要
肺高血压(pulmonary hypertension,PH)是终末期肾病(end-stage renal disease,ESRD)患者常见的一种并发症,尤以血液透析(hemodialysis,HD)患者最为常见,多呈进行性发展且预后不良,最终可导致右心衰竭甚至死亡。PH是ESRD患者病死率增加的独立危险因素,临床工作中对该类患者应予以重视,以便早期发现、预防及治疗。ESRD患者PH的发病机制尚不明确,可能与肺血管阻力、肺血流量及肺小动脉楔压的增加有关,慢性缺氧、血管钙化、炎症等危险因素的存在促进其发生发展。
Pulmonary hypertension (PH) is a common complication in patients with end-stage renal disease (ESRD),especially in patients with hemodialysis (HD).Poor prognosis can eventually lead to right heart failure and even death.PH is an independent risk factor for increased mortality in ESRD patients.We should pay attention to these patients in clinic for early detection,prevention and treatment.The pathogenesis of PH in ESRD patients is still unclear so far,which might be related to the increase of pulmonary vascular resistance,pulmonary blood flow,and pulmonary arterial wedge pressure.In addition,the presence of risk factors can promote the development of PH,such as chronic hypoxia,vascular calcification,and inflammation.
作者
盛斌
朱腾腾
李江
SHENG Bin;ZHU Tengteng;LI Jiang(Department of Cardiology,Second Xiangya Hospital,Central South University,Changsha 410011,China)
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2019年第12期1419-1422,共4页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(81870233)~~
关键词
肺高血压
终末期肾病
血液透析
动静脉内瘘
pulmonary hypertension
end-stage renal disease
hemodialysis
arteriovenous fistula
