摘要
目的评价宫颈癌患者应用液基细胞学与人乳头状瘤病毒核酸联合检测的筛查效果。方法该研究纳入对象方便选取79例宫颈癌筛查患者,自2017年8月—2019年2月在该院接受宫颈癌筛查,为所有患者实施液基细胞学检查以及HR-HPV检查,分析液基细胞学检查、HR-HPV检查及联合检查特异度、准确度、灵敏度以及阳性预测值和阴性预测值。结果病理检查阴性率为35.44%,阳性率为64.56%。液基细胞学检查准确度为68.35%、特异度为57.14%、灵敏度为74.51%、阳性预测值为76.00%、阴性预测值为55.17%。HR-HPV检查准确度为69.62%、特异度为66.67%、灵敏度为70.69%、阳性预测值为85.42%、阴性预测值为45.16%。液基细胞学与HR-HPV联合检查准确度为92.41%、特异度为93.10%、灵敏度为92.00%、阳性预测值为95.83%、阴性预测值为87.10%。液基细胞学与HR-HPV联合检查结果准确度、灵敏度、特异度、阳性预测值以及阴性预测值均高于液基细胞学检查、HR-HPV检查,均差异有统计学意义(P<0.05)。结论宫颈癌患者应用液基细胞学与人乳头状瘤病毒核酸联合检测可使诊断效率得到明显提高,临床应用价值较高。
Objective To evaluate the screening effect of combined detection of liquid-based cytology and human papillomavirus nucleic acid in patients with cervical cancer.Methods A total of 79 patients with cervical cancer screening were included in the study.From August 2017 to February 2019,cervical cancer screening was convenient election performed in our hospital.Liquid-based cytology and HR-HPV examination were performed for all patients,and liquid-based cytology examination,HR-HPV examination and the specificity,accuracy,sensitivity,positive predictive value and negative predictive value of combined examination are analyzed.Results The negative rate of pathological examination was 35.44%,and the positive rate was 64.56%.The accuracyof liquid-based cytology was 68.35%,the specificity was 57.14%,the sensitivity was 74.51%,the positive predictive value was 76.00%,and the negative predictive value was 55.17%.Theaccuracy of HR-HPV examination was 69.62%,the specificity was 66.67%,the sensitivity was 70.69%,the positive predictive value was 85.42%,and the negative predictive value was 45.16%.Theaccuracy of liquid-based cytology and HR-HPV combined examinationwas 92.41%,the specificity was 93.10%,the sensitivity was 92.00%,the positive predictive value was 95.83%,and the negative predictive value was 87.10%.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of liquid-based cytology and HR-HPV combined test were higher than those of liquid-based cytology examination and HR-HPV examination.The difference was statistically significant(P<0.05).Conclusion The combination of liquid-based cytology and human papillomavirus nucleic acid detection inpatients with cervical cancer can significantly improve the diagnostic efficiency and the clinical value is high.
作者
桑明
Sang Ming(Department of Gynecology,the Second People’s Hospital of Huadian City,Huadian,Jilin,132400 China)
出处
《中外医疗》
2019年第34期193-195,共3页
China & Foreign Medical Treatment
关键词
液基细胞学
人乳头状瘤
病毒核酸检测
宫颈癌筛查
效果评价
Liquid-based cytology
Human papilloma
Viral nucleic acid detection
Cervical cancer screening
Effect evaluation
