摘要
原发性胆汁性胆管炎(PBC)是一种胆汁淤积性自身免疫性肝病,病程迁延,现部分患者临床治疗效果欠佳。肠道微生态系统主要由肠黏膜和肠道微生物群构成,与肝在功能、解剖上有着非常紧密的联系,并介肠-肝轴,参与维持机体的多种生理、免疫及代谢功能。分析肠道菌群与PBC之间的相互关系,或可为临床治疗PBC提供新的治疗思路。文章主要从肠道菌群失调与疾病的关系、肠道菌群及其代谢物与肝的交互作用、菌群移植在治疗PBC的潜在价值等方面进行综述。
Primary biliary Cholangitis(PBC)is a cholestatic autoimmune liver disease with a prolonged course and poor prognosis.The intestinal micro-ecological system is composed primarily by intestinal mucosa and gut microbiota.The system is closely related to the liver in function and anatomy,mediates the gut-liver axis and participates in maintaining various physiological,immune and metabolic functions of the body.Analysis of the relationship between the gut microbiota and PBC may provide new treatment ideas for clinical treatment of PBC.This article mainly reviews the relationship between gut microbiota imbalance and disease,the interac-tion of gut microbiota and its metabolites with the liver,and the potential value of fecal microbiota transplantation in the treatment of PBC.
作者
杨柳(综述)
徐丽红(审校)
YANG Liu;XU Li-hong(Department of Gastroenterology,the First Affiliated Hospital,Medical College of Shihezi University,Shihezi 832000,Xinjiang,China;Department of Gastroenterology,Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611130,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第12期1324-1328,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81360076)
