摘要
近年来,氯胺酮在精神疾病治疗中越来越受到重视。不同于5-羟色胺(5-HT)再摄取抑制剂,氯胺酮作为N-甲基-D-天冬氨酸(NMDA)受体拮抗剂的新型抗抑郁药,应用于难治性抑郁症患者,具有快速改善患者抑郁症状及显著降低自杀风险的优势。本文对氯胺酮用于抗抑郁治疗的研究进展进行综述。
In recent years,ketamine has been paid increasing attention in the treatment of mental illness.As the new antidepressant,ketamine is N-methyl-D-aspartate(NMDA) receptor antagonist,which is different from the 5-serotonin(5-HT) reuptake antidepressant,applied to patients with treatment-resistant depression.It can improve patients’ depressive symptoms quickly and reduce the risk of suicide significantly.This article reviews the research progress of ketamine in anti-depression treatment.
作者
陈自悦
肖玲
王惠玲
王高华
CHEN Zi-yue;XIAO Ling;WANG Hui-ling;WANG Gao-hua(Mental Health Center,the People's Hospital of Wuhan University,Wuhan 430060,China)
出处
《临床精神医学杂志》
2019年第6期426-428,共3页
Journal of Clinical Psychiatry
