摘要
目的研究尾吊模拟失重大鼠灌胃给予莫西沙星后的尿液排泄规律,为在空间飞行中合理使用莫西沙星提供基础实验数据。方法采用3周尾吊大鼠模型模拟失重效应,单次灌胃80mg/kg莫西沙星后,收集0~4,4~8,8~12,12~24,24~48,48~72h时间段尿液样本,采用HPLC-MS法测定大鼠尿液中莫西沙星的含量,计算尿液中药物的累积排泄量。结果给药后8h内,莫西沙星在对照组排泄量即明显高于尾吊模拟失重组(P<0.01),且在两组大鼠尿液中累积排泄量的差异持续至给药后72h。给药72h后,尾吊组和对照组大鼠尿液中莫西沙星累积排泄量分别为(4.979±4.36)μg、(12.96±1.61)μg,莫西沙星在模拟失重组大鼠累积排泄量下降为对照组的38.4%(P<0.01)。结论尾吊模拟失重显著降低了莫西沙星在大鼠尿液中的排泄量。
Objective To study the urine excretion of moxifloxacin in simulated weightlessness rats after oral administration,which might provide basic experimental data for further use of moxifloxacin in spaceflight.Methods After three weeks of tail suspension to simulate weightlessness,rats were orally administered with a single dose of 80 mg/kg moxifloxacin.Then,the urine samples were collected at0~4,4~8,8~12,12~24,24~48,48~72 hafter administration,and the content of moxifloxacin was determined by HPLC-MS.The urine excretion percentage and excretion volume were calculated.Results Within 8 hafter administration,the excretion of moxifloxacin in the control group was significantly higher than that of tail-suspension simulated weightlessness group(P<0.01),and the difference of cumulative excretion in rat urine between the two groups lasted to 72 hafter administration.At 72 hpost ingestion,the cumulative excretion of moxifloxacin in tail-suspension group and control group was(4.979±4.36)μg and(12.96±1.61)μg,respectively.The cumulative excretion of moxifloxacin in simulated weightlessness rats decreased to 38.4%of the control group(P<0.01).Conclusion Simulated weightlessness by tail-suspension significantly reduces the urine excretion of moxifloxacin in rats.
作者
刘骅焱
李勇枝
王佳平
高建义
王睿
李玉娟
Liu Huayan;Li Yongzhi;Wang Jiaping;Gao Jianyi;Wang Rui;Li Yujuan(School of Life Science,Beijing Institute of Technology,Beijing 100081,China;不详)
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2019年第6期478-483,共6页
Space Medicine & Medical Engineering
基金
1226工程卫生专业重大项目(AWS16J018)
