摘要
莫西沙星(moxifloxacin)属第四代氟喹诺酮类抗菌药物。莫西沙星通过抑制细菌的DNA螺旋酶A亚单位和拓扑异构酶IV的活性,阻断DNA的复制,从而发挥杀菌作用。对革兰阴性菌、阳性菌均有强大的抗菌能力,对支原体、衣原体、军团菌有效,对厌氧菌感染有效,尤其对某些临床常见的耐药菌有效。临床应用莫西沙星治疗社区获得性肺炎、急性细菌性鼻窦炎、泌尿生殖系感染、继发性腹膜炎、肺结核的早期及延长早期间治疗、强直性脊椎炎和皮肤、皮下组织感染的治疗。
Moxifloxaein is one of the newly applied antibiotics fourth belonging to the forth generation of fluoroquinolone druds. This antibiotic can kill bacteria by inhibiting the activities of DNA heliease subunit A and topoismerase IV and blocking DNA reproduce copy. The moxifloxaein has a powerful ability against both the Gram-negative and Grampositive bacteria including Mycoplasma, Chlamydia and Legionella. It has fine therapeutic effects to anaerobic infections and especially to some common drug resistant bacterial infections. In clinic, moxifloxaein was applied to treat community acquired pneumonia, acute bacterial sinusitis, urogenital system infections, secondary peritonitis, early and extended pulmonary tuberculosis, ankylosing spondylitis, skin and subcutaneous tissue infections.
出处
《微生物学杂志》
CAS
CSCD
2007年第5期98-101,共4页
Journal of Microbiology
关键词
莫西沙星临床应用抗感染作用
Moxifloxaein
Clinical application
Anti-infection
