摘要
目的:探讨女性妊娠次数与绝经后冠心病(CHD)的关系。方法:选择诊断为CHD的绝经后女性389例为病例组,非CHD的绝经后女性151例为对照组,两组资料进行比较和分析。结果:CHD组女性的体重指数(BMI)、高血压和糖尿病的患病率、血脂水平以及妊娠次数均显著高于非CHD组女性,且其初次生产年龄更小(均P<0.05)。相关性分析显示,妊娠次数为1、2、3、≥4的绝经后女性CHD的患病风险分别比未曾妊娠的绝经后女性高6%(OR=1.06,95%CI:1.01~1.59,P=0.021)、12%(OR=1.12,95%CI:0.96~1.66,P=0.163)、23%(OR=1.23,95%CI:1.10~1.75,P=0.004)和38%(OR=1.38,95%CI:1.31~3.27,P<0.001)。结论:妊娠次数增加是绝经后女性患CHD的独立危险因素。
Objective:To explore the relationship between pregnancies and coronary heart disease(CHD)in postmenopausal women.Methods:This study included 389 CHD and 151 non-CHD postmenopausal women.The data in two groups were compared and analyzed.Results:Compared with the non-CHD group,postmenopausal women with CHD had significantly higher BMI,prevalence of hypertension and diabetes,blood lipid level,and pregnancies,as well as younger in age at first birth(all P<0.05).The correlation analysis showed that the CHD risk of gestational times of 1,2,3 and greater than or equal to 4 were increased by 6%(OR=1.06,95%CI:1.01 to 1.59,P=0.021),12%(OR=1.12,95%CI:0.96 to 1.66,P=0.163),23%(OR=1.23,95%CI:1.10 to 1.75,P=0.004)and 38%(OR=1.38,95%CI:1.31 to 3.27,P<0.001)when compared with the women without pregnancy,respectively.Conclusion:The increase of pregnancies is an independent risk factor for CHD in postmenopausal women.
作者
帅维
王辉波
Shuai Wei;Wang Huibo(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430061,China)
出处
《巴楚医学》
2019年第4期8-11,24,共5页
Bachu Medical Journal
基金
国家自然科学基金项目（No:81670333）
关键词
妊娠次数
绝经
冠心病
number of pregnancies
menopause
coronary heart disease
