脂肪因子在心肌缺血再灌注损伤中的研究进展被引量：4

The emerging role of adipokines in myocardial ischemia reperfusion injury: a literature review

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摘要 1 心肌缺血再灌注损伤概述缺血性心脏病发病率和死亡率高,是全世界患者的主要死亡原因。目前,药物溶栓、介入、冠状动脉旁路移植术等血管再通和心脏辅助技术是治疗缺血性心脏病的有效手段,再通技术使缺血区域动脉血流重新恢复的同时也使心肌组织面临"二次打击",表现为心肌细胞坏死、组织结构紊乱和器官功能损害进一步加重,即心肌缺血再灌注(myocardial ischemia reperfusion,MI/R)[1]损伤。

作者朱丽雯谭延振张正斌张冰冯攀马继鹏文亮罗文平 Zhu Liwen;Tan Yanzhen;Zhang Zhengbing

机构地区陕西中医药大学第二临床医学院空军军医大学第一附属医院心血管外科空军军医大学第一附属医院老年病科空军军医大学第一附属医院心血管内科

出处《中国体外循环杂志》 2019年第6期378-384,共7页 Chinese Journal of Extracorporeal Circulation

基金国家自然科学基金项目(81600295,81600356,81570231)

关键词缺血再灌注损伤脂肪因子心肌保护心血管疾病 Ischemia reperfusion injury Adipokine Myocardial protection Cardiovascular disease

分类号 R54 [医药卫生—心血管疾病]

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参考文献5

1熊红燕,杨阳,李珊,金振晓,陆莎,王鑫,庞雅桢,王瑞,吴媛,宋国玲.缺血预处理对糖尿病心肌缺血再灌注损伤保护作用的研究进展[J].中国体外循环杂志,2012,10(3):185-188. 被引量：4
2Niki KATSIKI,Dimitri P MIKHAILIDIS,Maciej BANACH.Leptin, cardiovascular diseases and type 2 diabetes mellitus[J].Acta Pharmacologica Sinica,2018,39(7):1176-1188. 被引量：49
3袁倩倩,韩加.抵抗素与氧化应激在代谢综合征发病机制中的研究进展[J].医学综述,2013,19(4):597-599. 被引量：4
4左红,魏亚静,侯文兵,石晓辉,孙小霞.抵抗素与稳定性冠心病病死率的相关性研究[J].西南国防医药,2018,28(6):563-565. 被引量：3
5陈艳华.脂联素合内脂素对急性心肌梗死PCI术后心力衰竭的意义[J].实用中西医结合临床,2018,18(4):112-113. 被引量：4

二级参考文献62

1顾东风,Reynolds K,杨文杰,陈恕凤,吴锡桂,段秀芳,蒲晓东,徐丽华,吴先萍,陈祥福,魏仁敏,陈娜萦,吴天一,王礼桂,姚才良,牟建军,马义峰,王晓飞,Whelton P,何江.中国成年人代谢综合征的患病率[J].中华糖尿病杂志（1006-6187）,2005,13(3):181-186. 被引量：581
2HongCHEN,Xing-junWU,Xi-yuanLU,LiangZHU,Li-pingWANG,Huang-tianYANG,Hong-zhuanCHEN,Wen-junYUAN.Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats[J].Acta Pharmacologica Sinica,2005,26(7):806-812. 被引量：11
3梁梅花,李强,张巾超,刘枫晨,卢斌,郑守华,孙玉倩.抵抗素与肥胖及2型糖尿病的关系[J].中国糖尿病杂志,2007,15(7):418-420. 被引量：15
4Balakumar P, Rohilla A, Singh M. Pre conditioning and post conditioning to limit ischemia reperfusion induced myocardi al injury: what could be the next footstep [ J] ? Pharmacol Res, 2008, 57(6) :403 412.
5Murry CE, Jennings BB, Reimer KA. Preconditioning with is chemia: a delay of lethal cell injury in ischemic myocardium [ J]. Circulation, 1986,74(5 ) : 1124 1136.
6Tani M, Neely JR. Hearts from diabetic rats are more resistant to in vitro ischemia: possible role of altered Ca 2 + metabo lism. Cire Res, 1988,62(5) :931 940.
7Xu G, Takashi E, Kudo M, et al. Contradictory effects of short and long term hyperglycemias on iachemic injury of myocardium via intracellular signaling pathway [ J ]. Exp Mol Pathol, 2004,76 ( 1 ) :57 65.
8Hotta H, Miura T, Miki T, et al. Angiotansin II type I recep tor mediated upregnlatian of calcineurin activity underlies im pairment of cardiopretective signaling in diabetic hearts [ J ]. Circ Res, 2010, 106(1) :129 132.
9Kim HS, Cho JE, Hwang KC, et ul. Diabetes mellitus miti gates cardioprotective effects of remifentanil preconditioning in ischemia reperfused rat heart in association with anti apop totic pathways of survival[J]. Eur J Phatmacol, 2010,628( 1 3) :132 139.
10Jia JH, Chen KP, Chen SX, et al. Breviscapine, a traditional Chinese medicine, alleviates myocardial ischaemia reperfusion in jury in diabetic rats[J]. Acta Cardiol, 2008,63(6) :757 762.