摘要
目的:探究血凝酶联合奥美拉唑钠治疗对消化性溃疡患者胃酸分泌功能及血清表皮生长因子(EGF)、血管内皮生长因子(VEGF)和超氧化物歧化酶(SOD)水平的影响。方法:选取2017年2月至2019年2月于我院收治的消化性溃疡患者120例,根据治疗方法按比例筛选观察组(血凝酶联合奥美拉唑钠静脉注射)和对照组(奥美拉唑钠静脉滴注),各60例。比较两组止血效果相关指标、住院时间、溃疡创面愈合效果及治疗前后胃酸分泌功能指标变化与血清EGF、VEGF、SOD水平。结果:观察组出血量、输血量、止血时间、住院时间显著少于对照组,创面愈合总有效率显著高于对照组(P<0.05);治疗后两组胃酸分泌功能指标均显著降低,且观察组低于对照组(P<0.05);治疗后两组EGF、VEGF、SOD水平均显著提高,且观察组高于对照组(P<0.05)。结论:采用血凝酶联合奥美拉唑钠治疗止血效果较好,可调节胃酸分泌,促进溃疡创面愈合。
Objective: To explore the efficacy of hemocoagulase combined with omeprazole sodium on gastric acid secretion function and levels of serum EGF, VEGF and SOD in patients with peptic ulcer. Methods: A total of 120 patients with peptic ulcer admitted to our hospital from February 2017 to February 2019 were selected and divided into observation group(Hemagglutinase combined with omeprazole sodium is injected intravenously) and control group(Intravenous infusion of omeprazole sodium) according to the treatment method, with 60 cases in each group. The blood loss volume, blood transfusion volume, hemostasis time, hospital stay, healing effects of ulcer wounds and indexes of gastric acid secretion function [basic gastric acid secretion(BAO), maximum gastric acid secretion(MAO) and peak gastric acid secretion(PAO)] and levels of serum EGF, VEGF and SOD before and after treatment were recorded and compared between the two groups. Results: The blood loss volume and blood transfusion volume in observation group were significantly less than those in control group, and the hemostasis time and hospital stay were significantly shorter than those in control group(P<0.05). The total effective rate of wound healing in observation group was significantly higher than that in control group(P<0.05). The levels of BAO, MAO and PAO in the two groups were significantly decreased after treatment, and the levels in observation group were lower than those in control group(P<0.05). The levels of EGF, VEGF and SOD after treatment were significantly increased in the two groups, and the levels in observation group were higher than those in control group(P<0.05). Conclusion: Hemocoagulase combined with omeprazole sodium has better hemostasis effects on patients with peptic ulcer, and it can promote ulcer wound healing.
作者
申明
张铭光
王瑞
任宏飞
罗斌阳
SHEN Ming;ZHANG Mingguang;WANG Rui(West China Hospital of Sichuan University, Sichuan Chengdu 610041, China)
出处
《河北医学》
CAS
2019年第12期1941-1945,共5页
Hebei Medicine
基金
四川省卫生和计划生育卫生委员会科研课题,(编号:17PJ322)
