摘要
目的康复新液联合泮托拉唑治疗消化性溃疡的安全性分析。方法方便选择该院于2018年1月—2019年1月期间收治的88例消化性溃疡患者作为研究对象,结合患者入院就诊日期的奇偶性以及44例单组区间条件将患者划分为对照组(泮托拉唑治疗)、研究组(泮托拉唑联合康复新液治疗),对比分析两组患者治疗前后的胃动意(MTL)、胃泌素(GAS)、缩胆囊素(CCK)水平以及T淋巴细胞亚群水平、溃疡愈合时间、住院时间、不良反应发生率、1年内复发率。结果治疗后研究组的MTL水平(235.52±18.19)pg/mL、CD3+(74.47±5.33)%、CD4+(43.62±7.25)%高于对照组(214.27±19.03)pg/mL、(70.23±6.13)%、(38.84±6.32)%,GAS、CCK水平(70.26±6.33)ng/L、(12.55±2.52)ng/L、CD8+(27.64±4.12)%低于对照组的(80.42±9.64)ng/L、(14.23±2.76)ng/L、(29.73±4.42)%,溃疡愈合时间及住院时间(15.41±1.31)d、(20.40±2.50)d均优于对照组(20.49±2.87)d、(24.55±3.65)d,差异有统计学意义(t=5.354、3.462、3.297、5.844、2.982、2.294、10.681、6.222,P<0.05);研究组不良反应发生率(4.55%)与1年内复发率(2.27%)均低于对照组22.73%、18.18%,差异有统计学意义(χ^(2)=6.175、4.456,P<0.05)。结论康复新液联合泮托拉唑治疗消化性溃疡可有效纠正患者病情,在减少其复发风险的同时,还能为患者提供较好的安全保障,具有推广应用的价值。
Objective Safety analysis of Kangfuxin liquid combined with pantoprazole in the treatment of peptic ulcer.Methods The 88 patients with peptic ulcer admitted in the hospital from January 2018 to January 2019 were conveniently selected as the research objects,based on the parity of the patient's admission date and 44 single-group interval conditions,and the patients were divided into the control group(pantoprazole treatment)and study group(pantoprazole combined with Kangfuxin liquid treatment);comparative analysis of MTL,GAS,CCK levels,T lymphocyte subgroup levels,ulcer healing time,and hospitalization time of the two groups before and after treatment,incidence of adverse reactions,recurrence rate within 1 year.Results After treatment,the MTL levels of the study group(235.52±18.19)pg/mL,CD3+(74.47±5.33)%,CD4+(43.62±7.25)%were higher than those of the control group(214.27±19.03)pg/mL,(70.23±6.13)%,(38.84±6.32)%,GAS,CCK levels(70.26±6.33)ng/L,(12.55±2.52)ng/L,CD8+(27.64±4.12)%,lower than those of the control group(80.42±9.64)ng/L,(14.23±2.76)ng/L,(29.73±4.42)%,the ulcer healing time and hospitalization time(15.41±1.31)d,(20.40±2.50)d were better than those of the control group(20.49±2.87)d,(24.55±3.65)d,and the difference was statistically significant(t=5.354,3.462,3.297,5.844,2.982,2.294,10.681,6.222,P<0.05);the incidence of adverse reactions(4.55%)and the recurrence rate within 1 year(2.27%)in the study group were lower than those in the control group by 22.73%and 18.18%,the difference was statistically significant(χ^(2)=6.175,4.456,P<0.05).Conclusion Kangfuxin liquid combined with pantoprazole in the treatment of peptic ulcer can effectively correct the patient's condition and reduce the risk of recurrence.At the same time,it can also provide patients with better safety guarantee,which has the value of popularization and application.
作者
李芹芹
LI Qinqin(Department of Spleen and Stomach Diseases,Rushan Hospital of Traditional Chinese Medicine,Weihai,Shandong Province,264500 China)
出处
《中外医疗》
2021年第12期95-97,共3页
China & Foreign Medical Treatment
