摘要
目的探讨喜炎平注射液联合甲磺酸酚妥拉明注射液治疗重症肺炎的临床疗效。方法选取2017年4月-2018年12月在天津市宁河区医院就诊的82例重症肺炎患者为研究对象,所有患者按照随机数字表法分为对照组和治疗组,每组各41例。对照组静脉滴注甲磺酸酚妥拉明注射液,5 mg/次,2次/d。治疗组在对照组基础上静脉滴注喜炎平注射液,50 mg/次,2次/d。两组患者连续治疗1周。观察两组的临床疗效,比较两组的临床症状改善情况、血气指标、炎症因子。结果治疗后,对照组和治疗组的总有效率分别为80.49%、92.68%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组退热时间、咳嗽消失时间、肺部阴影消失时间、住院时间均明显短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组酸碱度(pH值)、血氧分压(p O2)、氧合指数(p O2/FiO2)明显升高,二氧化氮分压(p CO2)明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的血气指标明显优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的炎症因子水平明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论喜炎平注射液联合甲磺酸酚妥拉明注射液治疗重症肺炎具有较好的临床疗效,可改善临床症状和血气指标,减轻炎症反应,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Xiyanping Injection combined with Phentolamine Mesylate Injection in treatment of severe pneumonia. Methods Patients(82 cases) with severe pneumonia in Tianjin Ninghe Hospital from April 2017 to December 2018 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were iv administered with Phentolamine Mesylate Injection, 5 mg/time, twice daily. Patients in the treatment group were iv administered with Xiyanping Injection on the basis of the control group, 50 mg/time, twice daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and the improvement of clinical symptoms, blood gas indexes, and inflammatory factors in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.49% and 92.68%, respectively, and there was difference between two groups(P < 0.05). After treatment, antipyretic time, cough disappearance time, pulmonary shadow disappearance time, and hospitalization time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups(P < 0.05). After treatment, pH, p O2, and pO2/FiO2 in two groups were significantly increased, but the p CO2 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the blood gas indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of CRP, IL-6 and TNF-α in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the inflammatory factors in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Xiyanping Injection combined with Phentolamine Mesylate Injection has clinical curative effect in treatment of severe pneumonia, can improve clinical symptoms and blood gas indexes, and alleviate inflammation, which has a certain clinical application value.
作者
焦方刚
JIAO Fang-gang(Department of Intensive Care Unit,Tianjin Ninghe Hospital,301500 Tianjin,China)
出处
《现代药物与临床》
CAS
2019年第11期3280-3283,共4页
Drugs & Clinic
关键词
喜炎平注射液
甲磺酸酚妥拉明注射液
重症肺炎
血气指标
炎症因子
Xiyanping Injection
Phentolamine Mesylate Injection
severe pneumonia
blood gas index
inflammatory factor
