摘要
目的分析多巴胺+酚妥拉明治疗急诊重症肺炎合并心力衰竭的效果。方法选取2018年2月~2020年2月北京市顺义区医院收治的54例急诊重症肺炎合并心力衰竭患儿作为研究对象,按照随机数字表法分为对照组(27例)和实验组(27例)。对照组患者采用多巴胺治疗,实验组患者采用多巴胺+酚妥拉明治疗。比较两组患者的临床总有效率、炎症因子水平、心功能。结果实验组临床总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组的C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的比较,差异无统计学意义(P>0.05);治疗后,两组CRP、TNF-α、IL-6水平低于治疗前,实验组CRP、TNF-α、IL-6水平低于对照组,差异有统计学意义(P<0.05);治疗后,两组的心率、左心室舒张末期内径低于治疗前,左心室射血分数高于治疗前,差异有统计学意义(P<0.05);实验组的心率、左心室舒张末期内径低于对照组,左心室射血分数高于对照组,差异有统计学意义(P<0.05)。结论多巴胺+酚妥拉明治疗急诊重症肺炎合并心力衰竭的效果较单一药物治疗效果显著提升。
Objective To analyze the effect of Dopamine and Phentolamine in emergency severe pneumonia with heart failure.Methods A total of 54 children with severe pneumonia complicated with heart failure treated in the Hospital of Shunyi District of Beijing from February 2018 to February 2020 were selected as the research subjects.According to random number table method,they were divided into control group(27 cases)and experimental group(27 cases).The control group was treated with Dopamine,and the experiment group was treated with the combination of Dopamine and Phentolamine.The clinical total effective rates,inflammatory factor levels and cardiac functions of the two groups were compared.Results The total effective rate of the experiment group was higher than that of the control group,with statistically significant difference(P<0.05).Before treatment,the differences of C-reactive protein(CRP),tumor necrosis factor α(TNF-α),interleukin-6(IL-6)levels between the two groups were not statistically significant(P>0.05).After treatment,the levels of CRP,TNF-α and IL-6 in the two groups were lower than those before treatment,while the levels of CRP,TNF-α and IL-6 in the experimental group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the heart rate and left ventricular end diastolic diameter of the two groups were lower than those before treatment,and the left ventricular ejection fraction was higher than that before treatment,and the differences were statistically significant(P<0.05).Heart rate and left ventricular end diastolic diameter in experimental group were lower than those in control group,and left ventricular ejection fraction was higher than that in control group,with statistically significant differences(P<0.05).Conclusion Dopamine and Phentolamine was more effective than monotherapy in the treatment of emergency severe pneumonia with heart failure.
作者
鲁建光
LU Jian-guang(Department of Emergency,the Hospital of Shunyi District of Beijing,Beijing 101300,China)
出处
《中国当代医药》
CAS
2021年第4期48-50,共3页
China Modern Medicine
关键词
多巴胺
酚妥拉明
急诊重症肺炎
心力衰竭
Dopamine
Phentolamine
Emergency severe pneumonia
Heart failure
