摘要
目的探讨富含半胱氨酸蛋白61(Cyr61)蛋白在前列腺癌组织中的表达及其临床意义.方法选取我院前列腺癌组织(68例)和良性前列腺增生组织(60)例,应用免疫组织化学技术检测前列腺癌组织和良性前列腺增生组织中Cyr61蛋白的表达,并分析两组表达差异及Cyr61与前列腺癌病理学参数的关系.结果前列腺癌组织中Cyr61蛋白的表达较前列腺增生组织显著上升(85.3%比8.3%,x2=75.536,P<0.05);Cyr61蛋白表达与年龄(χ^2=0.297,P>0.05)、TNM分期编组(χ^2=0.342,P>0.05)、区域淋巴结转移(χ^2=0.176,P>0.05)、远处转移(χ^2=0.673,P>0.05)无明显相关,与术前总前列腺特异抗原(tPSA)水平(χ^2=8.492,P<0.05)、分化程度(χ^2=13.028,P<0.05)、Gleason评分(χ^2=4.032,P<0.05)明显相关.结论前列腺癌组织中Cyr61蛋白的表达显著上调,有助于评估前列腺癌的进展.
Objective To investigate the expression and clinical significance of Cysteine一rich protein 61(Cyi61)protein in prostate cancer.Methods We selected 68 cases of the prostate cancer tissues and 60 cases of benign prostatic hyperplasia tissues in our hospital.Immunohistochemistry was used to detect the expression of Cyi61 protein in prostate cancer tissues and benign prostatic hyperplasia tissues,and then the difference of expression between the two groups and its relationship with pathological parameters of prostate cancer were analyzed.Results The expression of Cyi61 protein in prostate cancer tissues was significantly higher than that in benign prostatic hyperplasia tissues(85.3%vs.8.3%,=75.536,P<0.05).Cyi61 protein expression was not correlated with age(χ^2=0.297,P>0.05),TNM staging(F=0.342,P>0.05),regional lymph node metastasis(χ^2=0.176,P>0.05)and distant metastasis(χ^2=0.673,P>0.05),but was significantly correlated with preoperative total prostate specific antigen(tPSA)level(χ^2=8.492,P<0.05),differentiation degree(χ^2=13.028,P<0.05)and Gleason scores(χ^2=4.032,P<0.05).Conclusion The expression of Cyi61 protein in prostate cancer tissues were significantly up-regulated,which helps to assess the progress of prostate cancer.
作者
徐海亮
顾朝辉
Xu Hailiang;Gu Chaohui(Department of Urology,Zhumadian Central Hospital,Zhumadian 463000,China;Department of Urology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第12期2141-2143,共3页
Chinese Journal of Experimental Surgery
