摘要
糖化血红蛋白(HbA1c)是监测糖尿病患者长期血糖控制情况的金标准,也是临床调整降糖治疗的重要依据。近年来,世界卫生组织(WHO)和许多国家的糖尿病学会将HbA1c纳入为糖尿病的诊断指标。血红蛋白变异体是影响HbA1c检测和结果解读的重要因素之一,血红蛋白变异体可以通过干扰某些HbA1c检测方法影响HbA1c结果,也可以通过改变红细胞寿命和(或)血红蛋白糖基化速率影响临床医生和实验室人员对HbA1c结果的正确解读。
Glycated hemoglobin(HbA1c)is the golden biomarker for clinical evaluation of long-term glycemic control,and also an important basis to guide adjustments to therapy.In recent years,the World Health Organization(WHO)and many national diabetes societies have recommended HbA1c as the preferred indicator for the diagnosis of diabetes.Hemoglobin variants are one of the factors affecting HbA1c values.On the one hand,they affect the results of HbA1c by interfering with some HbA1c detection methods,on the other hand,they affect the correct interpretation of HbA1c results by changing the life span of red blood cells and(or)the hemoglobin glycation rate.
作者
高冉
程歆琦
Gao Ran;Cheng Xinqi(Department of Clinical Laboratory,Peking Union Medical College Hospital,Peking Union Medical College&Chinese Academy of Medical Science,Beijing 100730,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2019年第11期899-903,共5页
Chinese Journal of Laboratory Medicine
