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警惕糖化血红蛋白A1c在地中海贫血患者中误用 被引量：6

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摘要 毛细管电泳法检测3例不同基因突变和缺失的地中海贫血患者结果显示3例患者Hb均异常,用阳离子交换高效液相色谱法(IE-HPLC)检测其糖化血红蛋白A1c(HbA1c)图谱均出现异常,而用硼酸盐亲和层析法、免疫比浊法检测结果均在仪器可报告范围内,但该结果并不能代表患者HbA1c水平。检测HbA1c时要了解患者的Hb是否存在异常,以避免指标误用。
作者 索明环 温冬梅 张秀明 陈亚琼 吴剑杨
机构地区 中山大学附属中山医院检验医学中心
出处 《临床检验杂志》 CAS CSCD 北大核心 2014年第2期151-152,共2页 Chinese Journal of Clinical Laboratory Science
基金 中山市科技局资助课题(20122A034)
关键词 血红蛋白A 糖基化 糖化血红蛋白A1C 地中海贫血
分类号 R446.5 [医药卫生—诊断学]
  • 相关文献

参考文献4

  • 1李卿,居漪.糖化血红蛋白A1c的检测方法和干扰因素[J].临床检验杂志,2012,30(6):418-420. 被引量：18
  • 2Xu XM, Zhou YQ, Luo GX, et al. The prevalence and spectrum of alpha and 13 thalassemia in Guangdong province : implications for the future health burden and populantion screening [ J 1. J Clin Pathol, 2004, 57(5) :517-522.
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二级参考文献17

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共引文献17

同被引文献58

  • 1王平,黄耀熊.激光拉曼光谱法研究乙醇对血红蛋白结构的影响[J].中国医学物理学杂志,2011,28(3):2674-2676. 被引量：5
  • 2孙长伟,谭戈,李兴阳.HPFH合并糖尿病1例HbA_1c测定分析[J].中国冶金工业医学杂志,2006,23(6):729-729. 被引量：1
  • 3杨有业,张秀明.临床检验方法学评价[M].北京:人民卫生出版社,2008:118-127.
  • 4刘丁,陈伟.氨甲酰血红蛋白的研究现状[J].国外医学（临床生物化学与检验学分册）,1997,18(3):105-107. 被引量：2
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  • 7吕灿荤,刘金波,朱钦霞.微柱层析法检测糖基化血红蛋白的临床意义[J].皖南医学院学报,1986,6(2):89-92.
  • 8American Diabetes Association. Diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 2010, 33 Suppl 1: $62- $69.
  • 9Polage C, Little RR, Rohlfing CL, et al. Effects of beta thalassemia minor on results of six glycated hemoglobin methods [J]. Clin Chim Acta, 2004, 350(1-2) : 123-128.
  • 10Little RR, Rohlfing CR, Hanson S, et al. Effects of hemoglobin E and D traits on glycated hemoglobin ( HbAlc ) measurements by twenty-three methods [ J ]. Clin Chem, 2008, 54 ( 8 ) : 1277- 1282.

引证文献6

二级引证文献20

临床检验杂志
2014年 第2期

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