摘要
钙离子(Ca2+)是重要的第二信使,在调节基因表达、细胞周期调控、细胞运动、自噬和凋亡等方面发挥着重要的作用。活性氧(ROS)由细胞内系统以中等水平生成,作为信号分子参与各种生理活动,而高水平的ROS可致功能障碍、疾病甚至细胞死亡。越来越多的证据表明,Ca2+和ROS信号系统之间存在相互联系,这对调节细胞信号网络具有重要意义。Ca2+和ROS信号系统之间的相互作用可以是刺激性或抑制性,这取决于靶蛋白的类型、ROS种类、剂量和暴露时间。这种复杂的联系可能会增强信号转导,其中一个系统的功能障碍可能会影响另一个,并破坏两个系统的稳定性。该综述简要总结了Ca2+和ROS系统之间的相互调节作用,此调节有利于维持Ca2+和ROS稳态。
Calcium ion(Ca^2+)is an important secondary messenger and plays an essential role in regulating gene expression,cell cycle control,cell motility,autophagy and apoptosis.Reactive oxygen species(ROS)are generated in moderate levels by different intracellular systems,acting as signaling molecules involved in various physiological processes,while high levels of ROS can cause dysfunction,diseases,and even cell death.Increasing evidence suggests a mutual cross-talk between Ca^2+and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks.The interactions between Ca^2+and ROS signaling systems can be either stimulatory or inhibitory,depending on the type of target proteins,the ROS species,the dose,and exposure time.Such complex connection might enhance signal transduction,whereas dysfunction in either system might affect the other system and undermine the stability of both systems.This review briefly summarizes the interactions between the two signaling systems that finely tune the homeostasis of Ca^2+and ROS.
作者
侯晓媛
李雪
鲁严
HOU Xiaoyuan;LI Xue;LU Yan(Department of Dermatology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Dermatology,Obstetrics and Gynecology Hospital Affiliated of Nanjing Medical University,Nanjing 210004,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第9期1837-1844,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81872541、81602774)资助的课题~~
关键词
活性氧
钙离子
钙离子通道
reactive oxygen species
calcium ion
Ca^2+channels
