摘要
目的分析甲泼尼龙琥珀酸钠联合红霉素治疗类百日咳综合征的临床疗效。方法选择我院2014年5月至2018年7月收治的60例类百日咳综合征患儿,随机分为对照组和研究组,每组30例。对照组接受静脉滴注联合雾化吸入红霉素治疗,雾化吸入一日2次,每次10 mg/kg,持续治疗7~10 d。研究组在此基础上加用甲泼尼龙琥珀酸钠进行治疗,静脉滴注甲泼尼龙琥珀酸钠,一日2次,每次1 mg/kg,持续治疗5~7 d。比较分析两组患儿有效率、临床症状缓解时间、住院时间,白细胞(white blood cell,WBC)计数以及血清C反应蛋白(C-reactive protein,CRP)水平。结果治疗前,两组患者WBC、血清CRP水平无显著差异(P>0.05);治疗后,研究组总有效率明显高于对照组(93.33%对73.33%),差异有统计学意义(P<0.05)。研究组患者咳嗽减轻时间[(4.50±1.01)d对(6.30±1.65)d]、咳憋消失时间[(6.07±1.32)d对(7.63±1.89)d]及住院时间[(8.43±2.61)d对(10.47±3.75)d]均少于对照组,差异具统计学意义(P<0.05)。治疗后,两组WBC、血清CRP水平均下降,且研究组低于对照组[WBC:(5.93±0.85)×109/L对(9.40±1.20)×109/L;CRP:(1.76±0.21)mg/L对(4.80±0.65)mg/L],差异有统计学意义(P<0.05)。结论甲泼尼龙琥珀酸钠联合红霉素在类百日咳综合征治疗可改善临床症状,减轻炎症反应,有较大临床应用价值。
Objective To analyze the clinical efficacy of methylprednisolone sodium succinate combined with erythromycin in the treatment of pertussis syndrome.Methods A total of 60 children with pertussis syndrome who treated from May 2014 to July 2018 in our hospital were enrolled and randomly divided into control group and research group with 30 cases in each group.The control group was treated with intravenous erythromycin combined with atomized erythromycin inhalation.Erythromycin nebulized inhalation was 10 mg/kg,2 times one day continuous for 7~10 d.For the research group,methylprednisolone sodium succinate were added on:intravenous bolus injection of 1 mg/(kg·d)methylprednisolone sodium succinate,2 times one day for continuous 5~7 d.Clinical efficacy rate,symptom remission time and days of hospital stay,white blood cell(WBC)count and serum C-reactive protein(CRP)were compared between the two groups.Results Before treatment,there was no significant difference of levels of WBC count and serum CRP between the two groups(P>0.05).After treatment,the total efficacy rate in the research group was significantly higher than that in the control group(93.33%vs 73.33%),and the difference was statistically significant(P<0.05).The duration of cough relief[(4.50±1.01)d vs(6.30±1.65)d],the disappearance time of cough and holding[(6.07±1.32)d vs(7.63±1.89)d],the length of hospital stay[(8.43±2.61)d vs(10.47±3.75)d]are less than the control group.The difference was statistically significant(P<0.05).After treatment,the WBC and serum CRP in both groups were decreased,and the research group was lower than the control group[WBC:(5.93±0.85)×109/L vs(9.40±1.20)×109/L;CRP:(1.76±0.21)mg/L vs(4.80±0.65)mg/L].The difference was statistically significant(P<0.05).Conclusion Methylprednisolone sodium succinate combined with erythromycin may help to improve clinical symptoms and reduce inflammatory reaction of pertussis syndrome.It has great clinical application value.
作者
马骥
徐凤琴
毕良学
MA Ji;XU Feng-qin;BI Liang-xue(Department of Respiratory Medicine,Anhui Children's Hospital,Hefei 230051,Anhui Province,China)
出处
《世界临床药物》
CAS
2019年第10期728-731,736,共5页
World Clinical Drug
关键词
类百日咳综合征
甲泼尼龙琥珀酸钠
红霉素
疗效
pertussis syndrome
methylprednisolone sodium succinate
erythromycin
clinical efficacy
