摘要
Ti Ni alloys, with their unique shape memory effects and super elastic properties, occupy an indispensable place in the family of metallic biomaterials. In the past years, surface treatment is the main technique to improve the bioinert nature of microcrystalline Ti Ni alloys and inhibit on the release of toxic nickel ions to obtain excellent osteogenesis and osseointegration function. In the present study, nanocrystalline Ti49.2Ni50.8 alloy has been fabricated via equal channel angular pressing(ECAP), and the in vitro and in vivo studies revealed that it had enhanced cell viability, adhesion, proliferation, ALP(Alkaline phosphatase)activity and mineralization, and increased periphery thickness of new bone, in comparison to the commercial coarse-grained counterpart. These findings indicate that the reduction of grain size is beneficial to increasing the biocompatibility of Ti49.2Ni50.8 shape memory alloy.
Ti Ni alloys, with their unique shape memory effects and super elastic properties, occupy an indispensable place in the family of metallic biomaterials. In the past years, surface treatment is the main technique to improve the bioinert nature of microcrystalline Ti Ni alloys and inhibit on the release of toxic nickel ions to obtain excellent osteogenesis and osseointegration function. In the present study, nanocrystalline Ti49.2Ni50.8 alloy has been fabricated via equal channel angular pressing（ECAP）, and the in vitro and in vivo studies revealed that it had enhanced cell viability, adhesion, proliferation, ALP（Alkaline phosphatase）activity and mineralization, and increased periphery thickness of new bone, in comparison to the commercial coarse-grained counterpart. These findings indicate that the reduction of grain size is beneficial to increasing the biocompatibility of Ti49.2Ni50.8 shape memory alloy.
基金
supported by the National Key R&D Program of China (No. 2018YFC1106600)
National Natural Science Foundation of China (NSFC)
the Russian Foundation for Basic Research (RFBR) NSFC-RFBR Cooperative Project (No. 51611130054)
the National Natural Science Foundation of China (Nos. 51431002 and 51871004)
the National Natural Science Foundation of China (NSFC)
the Research Grants Council (RGC) of Hong Kong NSFC-RGC Joint Research Scheme (Grant No. 5161101031)
the financial support from Saint Petersburg State University in the framework of Call 3 project (id 26130576)
