摘要
目的探讨胺碘酮联合美托洛尔在急性心肌梗死合并心律失常患者中的效果及对患者心脏功能的影响。方法选择2017年6月至2018年12月急性心肌梗死合并心律失常患者92例作为对象,按随机数字表法分为对照组(46例)和观察组(46例)。2组入院后均给予常规方法治疗,对照组给予胺碘酮治疗,观察组在对照组基础上联合美托洛尔治疗,3周疗程后对患者效果进行评估,比较2组心脏功能、心肌损伤指标及药物安全性。结果观察组治疗后3周左室舒张末期内径(LVEDD)水平,低于对照组(P<0.05);观察组治疗后3周左心室射心分数(LVEF)、心输出量(CO)水平,高于对照组(P<0.05);观察组治疗后3周肌酸激酶同工酶(CK-MB)、肌酸肌酶(CK)、脑钠肽(BNP)、N末端脑钠肽前体(NT-proBNP)水平,低于对照组(P<0.05);2组治疗过程中心动过缓、低血压、肝肾异常、静脉炎、腹泻或便秘发生率比较差异无统计学意义(P>0.05)。结论胺碘酮联合美托洛尔用于急性心肌梗死合并心律失常患者中能提高患者心脏功能,改善心肌损伤,且未增加药物不良反应发生率,值得推广应用。
Objective To investigate the effect of amiodarone combined with metoprolol in patients with acute myocardial infarction complicated with arrhythmia and its effect on cardiac function.Methods A total of 92 patients with acute myocardial infarction complicated with arrhythmia from June 2017 to December 1818 were enrolled.They were randomly divided into control group(n=46 cases)and observation group(n=46 cases).The two groups were treated with conventional methods after admission.The control group was treated with amiodarone.The observation group was treated with metoprolol on the basis of the control group.The effect of the patients was evaluated after 3 weeks of treatment.The two groups were compared for cardiac function and myocardial injury indicators and drug safety.Results The level of LVEDD in the observation group was lower than that in the control group(P<0.05).The level of LVEF and CO in the observation group was higher than that in the control group(P<0.05).The levels of CK-MB,CK,BNP and NT-proBNP were lower than those in the control group(P<0.05).There were no statistical significance for the incidence of bradycardia,hypotension,liver and kidney abnormalities,phlebitis,diarrhea or constipation in the two groups.Conclusion Amiodarone combined with metoprolol can improve cardiac function and improve myocardial injury in patients with acute myocardial infarction and arrhythmia,and it does not increase the incidence of adverse drug reactions.It is worthy of popularization and application.
作者
李西红
孙黎博
Li Xihong;Sun Libo(Department of Internal Medicine,Third Hospital of Xi′an,Shaanxi 710018,China)
出处
《山西医药杂志》
CAS
2019年第22期2734-2737,共4页
Shanxi Medical Journal
关键词
胺碘酮
美托洛尔
急性心肌梗死
心律失常
心性
心脏功能
Amiodarone
Metoprolol
Acute myocardial infarction
Arrhythmias
cardiac
Cardiac function
