摘要
目的探讨银杏叶片联合吡拉西坦片治疗血管性痴呆的临床效果。方法选择2017年1月~2018年5月在上海市崇明区中兴镇社区卫生服务中心进行治疗的血管性痴呆患者78例,按照随机数字的方法分为对照组(n=39)和观察组(n=39),对照组给予吡拉西坦,观察组在对照组治疗基础上使用银杏叶片,对治疗的效果进行分析。结果经过治疗后,两组患者的长谷川痴呆量表(HDS)及简易智力状态检查量表(MMSE)评分均增高,观察组增高的程度高于对照组(t=-6.509,-6.772,P<0.05),观察组治疗效果优于对照组,数据差异具有统计学意义(z=-3.172,P<0.05),两组患者的头晕[10.26%(4/39)vs.5.13%(2/39)],低血压[5.13%(2/39)vs.0],恶心[2.56%(1/39)vs.7.69%(3/39)],呕吐[5.13%(2/39)vs.2.56%(1/39)],发生率数据差异均无统计学意义(χ2=0.181,0.513,0.264,0.000,P>0.05)。结论使用银杏叶片联合吡拉西坦片治疗血管性痴呆患者,可以改善痴呆症状,提升治疗效果,安全性良好。
Objective To explore the clinical curative effect of ginkgo leaf tablets combined with piracetam tablets in treatment of vascular dementia.Methods From January 2017 to May 2018,78 patients with vascular dementia who were treated in Zhongxing Town Community Health Service Center of Chongming district in Shanghai were selected as the research objects.According to the random number method,they were divided into the control group(n=39)and the observation group(n=39).The control group was given piracetam while the observation group was treated with ginkgo leaf tablets on the basis of the control group.Curative effects of two groups were compared.Results After treatment,the scores of the Hasegawa Dementia Scale(HDS)and the Simple Mental State Examination Scale(MMSE)in both groups increased,and the degree of increase in the observation group was higher than that in the control group(t=-6.509,-6.772,P<0.05).The curative effect of the observation group was better than that of the control group,and the difference was statistically significant(z=-3.172,P<0.05).There was no statistically significant difference in the incidence of dizziness[10.26%(4/39)vs.5.13%(2/39)],hypotension[5.13%(2/39)vs.0],nausea[2.56%(1/39)vs.7.69%(3/39)]and vomiting[5.13%(2/39)vs.2.56%(1/39)]between the two groups(χ2=0.181,0.513,0.264,0.000,P>0.05).Conclusion Ginkgo leaf tablets combined with piracetam tablets in treatment of vascular dementia can improve the symptoms of dementia and improve the curative effects,which has good safety.
作者
徐惠丹
XU Huidan(Wards,Zhongxing Town Community Health Service Center of Chongming District,Shanghai 202163,China)
出处
《中国医药科学》
2019年第19期246-249,共4页
China Medicine And Pharmacy
关键词
银杏叶
吡拉西坦
血管性痴呆
脑组织
Ginkgo leaf
Piracetam
Vascular dementia
Brain tissue
