摘要
目的观察腹腔镜联合醋酸亮丙瑞林微球治疗子宫内膜异位症(EMS)伴不孕症的临床效果。方法选取2016年10月至2017年12月本院收治的78例EMS伴不孕症患者为研究对象,按照入院顺序将其分为对照组和联合组,每组39例。对照组行腹腔镜手术治疗,联合组行腹腔镜联合醋酸亮丙瑞林微球治疗。比较两组治疗前、后的PP14、HE4、CA125、CA199、FSH、LH、E2水平,治疗后不同时段的复发情况、妊娠情况以及临床疗效。结果治疗后,联合组血清PP14、HE4、CA125、CA199、FSH、LH、E2水平均明显低于对照组(P<0.05)。治疗后6、12个月,两组患者复发率均无显著差异(P>0.05)。治疗后6个月,两组患者妊娠率无显著差异(P>0.05);治疗后12个月,联合组妊娠率显著高于对照组(P<0.05)。联合组治疗总有效率为92.31%,明显高于对照组的69.23%(P<0.05)。结论腹腔镜联合醋酸亮丙瑞林微球治疗EMS伴不孕症的效果显著,可有效改善患者的临床症状,降低术后复发率,并提高妊娠率。
Objective To observe the clinical effect of laparoscopy combined with leuprolide acetate in the treatment of endometriosis(EMS)with infertility.Methods Seventy-eight patients with EMS and infertility admitted in our hospital from October 2016 to December 2017 were selected as the research objects.The patients were divided into control group and combined group according to the order of admission,with 39 cases in each group.The control group was treated with laparoscopic surgery,and the combined group was treated with laparoscopy combined with leuprolide acetate.The levels of PP14,HE4,CA125,CA199,FSH,LH and E2 before and after treatment,the recurrence and pregnancy outcome at different time after treatment and clinical effects were compared between the two groups.Results After treatment,the levels of serum PP14,HE4,CA125,CA199,FSH,LH and E2 in the combined group were significantly lower than those in the control group(P<0.05).At 6 and 12 months after treatment,there were no significant differences in recurrence rates between the two groups(P>0.05).At 6 months after treatment,there was no significant difference in pregnancy rates between the two groups(P>0.05).At 12 months after treatment,the pregnancy rate in the combined group was significantly higher than that in the control group(P<0.05).The total effective rate of treatment in the combined group was 92.31%,which was significantly higher than 69.23%of the control group(P<0.05).Conclusion Laparoscopy combined with leuprolide acetate in the treatment of EMS with infertility has a significant effect,which can effectively ameliorate the clinical symptoms,reduce the recurrence rate and improve the pregnancy rate.
作者
刘蔚
李小娟
郝媛
LIU Wei;LI Xiao-juan;HAO Yuan(Northwest Women's and Children's Hospital,Xi'an 710000,China)
出处
《临床医学研究与实践》
2019年第30期102-104,共3页
Clinical Research and Practice
