摘要
目的探讨抑郁症患者抑郁程度与甲状腺功能之间的相关性。方法连续性纳入初次就诊的抑郁症患者108例,分为研究组(合并甲状腺功能减退,n=31)和对照组(不合并甲状腺功能减退,n=77),比较2组患者汉密尔顿抑郁量表(HAMD)得分、抑郁症严重程度及血清甲状腺激素水平的差异,并分析HAMD评分与血清甲状腺激素水平的相关性。结果研究组HAMD评分和抑郁严重程度分级均显著高于对照组(P<0.01)。研究组血清三碘甲状原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)以及游离甲状腺素(FT4)浓度显著低于对照组(P<0.05或P<0.01),血清促甲状腺素(TSH)浓度明显高于对照组(P<0.01)。相关性分析发现,抑郁患者HAMD评分与血清T3(r=-0.269,P<0.05)、T4(r=-0.331,P<0.05)及FT4(r=-0.427,P<0.01)水平呈负相关,与血清TSH水平呈正相关(r=0.459,P<0.01)。结论抑郁症患者抑郁严重程度与甲状腺功能密切相关,需综合治疗。
Objective To investigate the correlation between thyroid function and degree of depression in patients with depression.Methods A total of 108 cases with depression were continuously collected and were divided into a study group(combined with hypothyroidism,n=31)and a control group(not combined with hypothyroidism,n=77).Hamilton depression rating scale(HAMD)score,difference in serum thyroid hormone concentration and severity of depression were compared between the two groups,and the correlation between HAMD scores and serum thyroid hormone concentration were analyzed.Results HAMD score in the study group was significantly higher than that of the control group(28.45±5.39 vs.22.79±4.67,P<0.01).Serum triiodothyronine(T3),thyroxine(T4),free triiodothyronine(PT3)and free thyroxine(FT4)concentrations in the study group were significantly lower than those in the control group(P<0.05 or P<0.01),and serum thyroid—stimulating hormone(TSH)concentration was significantly higher than that in the control group(P<0.01).Correlation analysis showed that HAMD score of depressed patients was negatively correlated with serum T3(r=-0.269,P<0.05),T4(r=-0.331,P<0.05)and FT4(r=-0.427,P<0.01)concentrations,and positively correlated with serum TSH concentrations(r=0.459,P<0.01).Conclusions The severity of depression is closely related to thyroid function in patients with depression,which requires comprehensive treatment.
作者
赵连俊
甘雪
邓健
徐雁
ZHAO Lianjun;GAN Xue;DENG Jian;XU Yan(Psychological Ward,Tangshan Fifth Hospital,Tangshan,Hebei 063004,China)
出处
《徐州医科大学学报》
CAS
2019年第7期534-536,共3页
Journal of Xuzhou Medical University
基金
河北省医学科学研究重点课题(ZL20140255)
关键词
抑郁症
甲状腺功能
相关性
depression
thyroid function
correlation
