摘要
目的 探讨肝细胞癌细胞中nm2 3 H1基因和C erbB 2基因的表达和其与SCT表现的关系。方法 对 3 6例经手术病理证实且行螺旋CT动、静脉双期增强扫描的肝细胞癌病例 ,观察其SCT表现特征 ,如包膜、子灶、门静脉癌栓、肝门淋巴结转移、肿瘤的大小和强化特征。用免疫组织化学的方法检测癌组织中nm2 3 H1基因和C erbB 2基因的表达情况。结果 肝细胞癌细胞中 ,nm2 3 H1阳性 2 1例 ,阳性率为 5 8.3 % ,转移高危组 (子灶、门脉癌栓、肝门淋巴结转移 )nm2 3 H1基因的表达低于转移低危组 (P <0 .0 5 ) ;C erbB 2基因阳性 2 2例 ,阳性率为 71.1% ,C erbB 2基因的表达在中等大小肝癌组表达高于小肝癌组和大肝癌组 (P <0 .0 5 )。结论 肝细胞癌的SCT表现与nm2 3 H1和C erbB
Objective To study the relationship between the expression of nm23 H1 gene,C erbB 2 gene and SCT findings in hepatocellular carcinoma (HCC).Method SCT scan was performed in 36 patients with pathologically proved hepatocellular carcinoma,and the expression of nm23 H1,C erbB 2 gene in tumor specimens was estimated with immunohistochemical SABC method.Result nm23 H1 protein positive rate of HCC specimens was 58.3%,nm23H1 protein positive rate was lower in high potential invasion and metastasis group (intrahepatic daughter foci,tumor emboli in portal veins,lymphaden metastasis).C erbB 2 protein positive rate of HCC specimens was 71.1%,C erbB 2 protein positive rate was higher in the group whose diameter is smaller than 5cm and equal to 5cm,and larger than 3cm than that whose diameter is smaller than 3cm and equal to 3cm,and was higher than that whose diameter is larger than 5cm.Conclusion This study shows the SCT findings of HCC is related with the expression of nm23 H1 and C erbB 2 gene.
出处
《潍坊医学院学报》
2002年第4期247-249,共3页
Acta Academiae Medicinae Weifang
基金
山东省科学技术委员会攻关项目资助课题(课题编号 :1 998BB1CCA1 )
