摘要
目的 :探讨妊高征病人母血、脐血中脂蛋白 (a) [Lp(a) ]及纤维结合蛋白 (Fn)水平变化在妊高征发生、发展中的作用。方法 :用免疫比浊法检测妊高征 30例 (中度 16例 ,重度 14例 )及正常足月妊娠 2 0例 (对照组 )的母血、脐血中的Lp(a)和Fn含量。 结果 :中、重度妊高征组母血中Lp(a)均较对照组极显著升高 (P <0 0 1) ;重度妊高征组脐静脉血Lp(a)含量较对照组和中度妊高征组显著升高 (P <0 0 5 )。中、重度妊高征组母血Fn含量均较对照组显著增高 (P <0 0 5 ) ;重度妊高征组脐静脉血Fn含量较对照组显著增高 (P <0 0 1)。结论 :血清中Lp(a)、Fn水平升高参与了妊高征的血管内皮损伤 ,观测这两项指标可以预测妊高征的严重程度及愈后。
Objective: Our aim was to investigate the changes of lipoprotein (a) and fibronectin (Fn) in the onset and development of pregnancy induced hypertension (PIH).Methods: The subjects were divided into PIH group (n=30, 16 moderate and 14 severe) and normal pregnancy group (n=20). The levels of Lp(a) and Fn in maternal and umbilical serum were detected by using immunoturbidimetry method.Results: (1)The levels of Lp(a) in maternal serum of patients with moderate PIH and severe PIH were significantly higher than that in the normalpregnancygroup (P<0 01). (2) The level of Lp(a) in umbilical vein of patients with severe PIH was significantly higher than those of normal pregnancy group and patients with moderate PIH (P<0 05).(3)The levels of Fn in maternal serum of patients with moderate PIH and severe PIH were significantly higher than that of normal pregnancy group (P<0 05).(4)The level of Fn in umbilical vein of patients with moderate PIH was significantly higher than that of normal pregnancy group (P<0 05).(5)The level of Fn in umbilical vein of patients with severe PIH was significantly higher than that of normal pregnancy group (P<0 01).Conclusion: The increases of Lp(a) and Fn in serum inolves in the lesion of endothelium. The changes of their levels can help in the diagnosis and prognosis of PIH.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2002年第5期373-375,共3页
Journal of China Medical University
关键词
脂蛋白(a)
纤维结合蛋白
妊娠高血压
心血管
lipoprotein(a)
fibronectin
pregnancy complications
hypertension
cardiovascular
