摘要
目的 :制备当归精油的 β 环糊精包合物并测定包合物中当归精油的包合率、释放率、溶出速率 ,探讨当归精油制成固体药物的可行性。方法 :用气相色谱 质谱法、X射线衍射法、薄层层析法对包合前后的挥发油进行研究。结果 :X射线衍射分析表明包合物完全不同于当归精油与 β 环糊精的混合物 ,已形成一种全新的物相 ,气相色谱 质谱法与薄层层析法检验结果证明当归精油的化学成分在包合前后没有发生变化。结论 :当归精油经 β 环糊精包合后其化学成分没有改变 ,增强了稳定性 ,制成制剂具有用量少、药效时间长、易于保存、服用方便等优点。
Objective: To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with β-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex. Method:GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound. Result:The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same. Conclusion: The results showed Angelica Sinensis essential oil was more stable with β-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.aydiffractiona
出处
《中国中药杂志》
CAS
CSCD
北大核心
2002年第11期832-834,845,共4页
China Journal of Chinese Materia Medica
关键词
剂型
当归精油
Β-环糊精
包合物
Angelica Sinensis essential oil
β-cyclodextrin
inclusion compound
