摘要
为探讨内皮素在心肌梗塞中的发病学意义,本实验在结扎大鼠前降支冠脉48 h的心肌梗塞模型上,观察内皮素抗血清对心肌梗塞大鼠的治疗作用。结果表明,心肌梗塞大鼠血浆内皮素含量显著升高。用特异的内皮素抗血清(ET-Ab)治疗心肌梗塞大鼠,可明显减小梗塞范围,降低其血浆脂质过氧化产物水平。提示,内皮素是心肌梗塞发病的重要体液因素之一。
In order to evaluate the pathogenetic role of endothelin (ET) in myocardial infarction, the effectof ET-antiserum on myocardial infarction was investigated on infarcted model produced by ligature ofleft anterior descending coronary artery in rats. The results showed that plasma ET elevated significa-ntly in rats with myocardial infarction (8.4±1.0 vs sham 3.1±0.2 pg/ml, P<0.01) and ET-antiserumadministration (0.5ml iv) dramatically decreased plasma ET level, reduced infarct size (22.4±2.4 vs43.6±2.8 IS/LV%, P<0. 01)and lowered plasma content of lipid peroxide(4.1±0.4 vs 5.6±0.5 nmol/ml, P<0.05), which suggests that ET is an important humoral factor which contributes to the pathog-enesis of myocardial infarction.
出处
《北京医科大学学报》
CSCD
1992年第1期33-35,共3页
Journal of Peking University(Health Sciences)
关键词
心肌梗塞
内皮素
抗血清
Myocardial infarction
Endothelin
Antiserum
