摘要
目的 :探讨针刺对偏头痛大鼠颈静脉血浆中血栓素B2 (TXB2 )和 6 -酮 -前列腺素F1α(6 -keb -PGF1α)的影响。方法 :将 4 0只大鼠随机分成 4组 ,分别为正常对照组、模型对照组、针刺对照组和针刺治疗组。采用电刺激三叉神经节诱导偏头痛大鼠 ,用放射免疫法测定大鼠颈静脉血浆中TXB2 和 6 -keto -PGF1α的含量。结果 :模型对照组较正常对照组TXB2 显著降低 (P <0 .0 5 ) ,6 -keto -PGF1α显著升高 (P <0 .0 1) ,TKB2 / 6 -keto -PGF1α比值显著降低 (P <0 .0 5 ) ;针刺治疗组较模型对照组TXB2 显著升高 (P <0 .0 5 ) ,6 -keto -PGF1α显著降低 (P <0 .0 5 ) ,TXB2 / 6 -keto -PGF1α比值显著升高 (P <0 .0 5 )。结论 :针刺可以调节偏头痛大鼠TXB2 和 6 -keto-PGF1α的代谢 ,维持血浆中TXB2 和 6 -keto -PGF1α的动态平衡。
Objective:To study effect of acupuncture on content of thromboxane B 2 (TXB 2) and 6-keto-prostaglandin F 1α (6-keto-PGF 1α ) of migraine.Methods:40 rats were randomly divided into four groups, which were normal control group, model control group, acupuncture control group and acupuncture treat group.The rats of migraine were induced by stimulating trigeminal ganglion with electricity. The content of plasma TXB 2 and 6-keto-PGF 1α were determined by radioimmunoassay.Results:Model control group was in contrast with normal control group:the level of plasma TXB 2 and TXB 2/6-keto-PGF 1α decreased significantly ( P <0. 05), while plasma 6-keto-PGF 1α level increased significantly ( P <0. 01);Acupuncture treat group was in contrast with model control group:The level of plasma TXB 2 and TXB 2/6-keto-PGF 1α increased significantly( P <0. 05),while plasma 6-keto-PGF 1α level decreased significantly ( P <0. 05). Conclusion:Acupuncture can regulate the metabolism of TXB 2 and 6-keto-PGF 1α in rats of migraine, and maintain the dynamic equilibrium of plasma TXB 2 and 6-keto-PGF 1α .
出处
《中国现代医学杂志》
CAS
CSCD
2002年第21期25-26,29,共3页
China Journal of Modern Medicine
