摘要
目的:探讨基质金属蛋白酶-2(matrixmetalloproteinase-2,MMP-2)和组织蛋白酶D(cathepsinD,CD)在胃癌组织中的表达与胃癌生物学行为、腹膜转移的关系。方法:应用免疫组织化学方法检测55例胃癌MMP-2和CD表达情况。其中45例行腹腔脱落细胞学检查。结果:MMP-2和CD与浸润深度、胃浆膜分型、腹腔脱落癌细胞和临床分期密切相关(P<0.01);CD与淋巴结转移显著相关(P<0.01),MMP-2与淋巴结转移无明显关系,但淋巴结转移阳性者MMP-2表达率高于淋巴结转移阴性者。结论:MMP-2和CD高表达胃癌具有更强的侵袭、淋巴结转移能力及腹膜转移倾向。MMP-2和CD能较好的反映胃癌的恶性生物学行为,有助于判断预后。结转移显著相关(P<0.01),MMP-2与淋巴结转移无明显关系,但淋巴结转移阳性者MMP-2表达率高于淋巴结转移阴性者。结论:MMP-2和CD高表达胃癌具有更强的侵袭、淋巴结转移能力及腹膜转移倾向。MMP-2和CD能较好的反映胃癌的恶性生物学行为,有助于判断预后。
Objective:To investigate the expressions of MMP-2and CD in gastric cancer and their relationships with biological behavior of gastric cancer and peritoneal dissemination.Methods :Immunohistochemical method was used to detect MMP-2and CD expressions in55patients with gastric cancer,45patients of them had intraperitoneal exfoliative cancer cell exami -nation.Results:The MMP-2and CD were closely correlated with the invasive depth,serosal type,in traperitoneal exfoliative cancer cell and clinical stages of the tumor(P<0.01)and CD was close ly related to the lymph node metastasis(P<0.01);No significant relationship was found be-tween MMP-2and lymph node metastasis,but MMP-2expression in lymph node metastasis group was higher than that in non-metastasis group.Conclusion:Gastric can cers with higher expression of MMP-2and CD denote stronger tissue invasion and lymph node metastasis and increased probability of peritoneal dissemination.MMP-2and CD could reflect the ma lignant bio logical be-havior of gastric cancer and predict the prognosis of disease.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第10期720-722,共3页
Chinese Journal of Clinical Oncology
基金
辽宁省科技厅攻关项目资助(编号2001225002-3)
