摘要
亚硒酸钠对胃癌细胞系SGC—7901有54％的杀伤能力,对人早幼粒白血病细胞(HL—60)生长有明显抑制作用。单独用于治疗小鼠移植性肿瘤S_(180)无效,联合大蒜治疗有较好效果。有可能硒是通过诱导癌细胞(如HL—60细胞)的成熟分化和阻断某些致癌物质(如MNNG)对正常细胞恶性转化,它能否起防癌作用值得进一步研究。
Our experimental results showed that sodium that sodium selenite possessed cytotoxic effect on gastric cancer cell line SGC7901 and inhibited the cell growth of human promyelocytic leukemia cell line HL-60. In combination with Allitridium it inhibited the growth of transplantable tumor S-180 in vivo, but not sodium selenite alone. It is possible that sodium selenite possessed its cancer preventive effect throngh its differentiation-inducing effect of malignant cells (such as HL-60), and the blocking effect of malignisa-tion of wormal cells in duced by carcinogens (such as MNNG).
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1992年第1期40-43,共4页
Chinese Journal of Cancer
关键词
肿瘤
实验
白血病
亚硒酸钠
Sodium Selenite Human Promyelocytic Leukemia Cell Line HL-60 Transformation of Human Fibroblast of Lung Embryo.
