摘要
目的:探讨慢性丙型肝炎患者血清丙肝抗体、HCVRNA载量及肝功能的关系。方法:分别用ELISA法、实时荧光定量PCR法及全自动生化仪对确诊的83例慢性丙肝患者血清进行丙肝抗体、HCVRNA载量及肝功能指标进行检测。结果:慢性丙型肝炎患者HCVRNA检出率显著低于丙型肝炎抗体,差异具有统计学意义(P<0.05),有病毒复制慢性丙肝患者ALT、AST水平显著高于无病毒复制者,差异均具有统计学意义(P<0.05),ALT、AST水平在高、中、低病毒复制组间差异均无统计学意义(P>0.05),ALT、AST水平并不随HCVRNA载量升高而升高。结论:综合检测HCV抗体和HCVRNA载量可以明确诊断慢性丙肝感染及判断病毒复制情况。病毒复制可造成肝脏炎症,但肝脏炎症程度并不随HCVRNA载量升高而升高。
Objective:To study the associations between anti-HCV antibody,HCV RNA and liver biochemical indicators in chronic HCV-infected patients.Method:Serum anti-HCV Antobody,HCV RNA quantitation and liver biochemical indicators were detected by ELISA,real-time quantitative RT-PCR and automatic biochenical analyzer from a total of 83 chronic HCV-infected inpatients enrolled from our hospital.Results:The detectable rate of HCV RNA was significantly lower than that of anti-HCV antibody(P<0.05).Serum ALT and AST levels from patients with HCV viremia were significantly higher than patients without HCV viremia(P<0.05).ALT and AST levels had no statistical significance among patients with high,average and low serum HCV RNA levels(all P>0.05).ALT and AST levels did not increase with the enhancement of HCV RNA levels.Conclusion:Chronc HCV infection and HCV replication status could be clearly diagnosized by combination of anti-HCV antoibody and HCV RNA detection.However,the intraheptic inflammatory injuries were showed no association with HCV RNA levels in chronic HCV-infected patients.
作者
陈继梅
施志农
李坤宝
CHEN Ji-mei;SHI Zhi-nong;LI Kun-bao(The Third Hospital of Wuhu,Wuhu 241000,Anhui)
出处
《安徽卫生职业技术学院学报》
2019年第5期96-97,100,共3页
Journal of Anhui Health Vocational & Technical College
