摘要
目的观察苓桂术甘汤联合益生菌治疗非酒精性脂肪性肝病(痰湿内阻型)患者的临床疗效。方法选取符合NAFLD诊断标准的患者96例,随机分为治疗组(苓桂术甘汤联合培菲康)及对照组(培菲康),各48例,连续治疗12周,停药后随访24周,观察2组治疗后谷丙转氨酶(ALT)、三酰甘油(TG)、总胆固醇(TC)、受控衰减参数(CAP)、中医证侯评分和疗效分析。结果中医证侯评分分析显示,治疗组临床总有效率为91.67%,优于对照组的52.08%,且中医证候积分改善优于对照组,差异具有显著性(P<0.05)。根据CAP评判为治疗组总有效率为81.25%,优于对照组的54.17%(P<0.05),且与对照组比较,治疗组能显著改善患者ALT、TG、CAP值水平(P<0.05),但对TC改善不明显(P>0.05)。结论苓桂术甘汤联合培菲康治疗非酒精性脂肪性肝病(痰湿内阻型)患者,能改善患者肝内脂变,降低三酰甘油,改善ALT,缓解临床症状。
Objective To observe the effectiveness of Linggui Zhugan Decoction with probiotics on nonalcoholic fatty liver disease of phlegm-dampness type. Methods 96 cases were equally divided into treatment group (Linggui Zhugan Decoction with Bifico) and control group (Bifico), and 48 cases in each group. All patients recieved 12- week medicine treatment continuously. The follow-up observation lasted for 24 weeks. ALT, triglycerides (TG), total cholesterol (TC), controlled attenuation parameter (CAP), TCM syndrome score and efficacy analysis were observed after treatment in the two groups. Results TCM syndrome score analysis showed that the total clinical response rate of the treatment group (91.67%) was significantly higher than that of the control group (52.08%), and TCM syndrome score of treatment group was improved significantly higher than that of the control group (P < 0.05). Compared with the control group, the level of ALT, TG and CAP value of the treatment group were significantly improved (P < 0.05) after 12-week treatment, but the difference of TC between the 2 groups was of no significance (P > 0.05). The total effective rate of CAP value of the treatment group (81.25%) was higher than that of the control group (54.17%) with significance (P<0.05). Conclusion Linggui Zhugan Decoction combined with Bifico treating with patients of NAFLD (phlegmdampness type) can improve intra-hepatic lipidosis and ALT, reduce triglyceride, and relieve clinical symptoms.
作者
喻晓
王雯婕
金嘉悦
潘洁露
张海燕
邢练军
YU Xiao;WANG Wenjie;JIN Jiayue;PAN Jielu;ZHANG Haiyan;XING Lianjun(Department Ⅱ of Digestive Diseases, Longhua Hospital Affiliated to Shanghai University of Traditional ChineseMedicine, Shanghai 200032, China;Department of Traditional Chinese Medicine, Xinzhuang Community Health Centre in Minhang District of Shanghai, Shanghai 201100, China;Beijing University of Chinese Medicine, Beijing 100029, China;Institute of Digestive Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China)
出处
《长春中医药大学学报》
2019年第5期891-894,共4页
Journal of Changchun University of Chinese Medicine
基金
龙医学者育苗计划(LYTD-40)
上海市浦东新区卫计委联合攻关项目(PW2016D-8)
上海市自然科学基金(17ZR1431000)
关键词
益生菌
非酒精性脂肪性肝病
苓桂术甘汤
probiotics
non-alcoholic fatty liver disease
Linggui Zhugan Decoction
