摘要
目的探讨雷贝拉唑联合抗幽门螺杆菌治疗HP感染的胃溃疡患者的临床疗效。方法选取2016年-2018年期间我院收治的HP感染引起的胃溃疡患者80例为研究对象,所有患者都应用四联疗法治疗,根据治疗药物种类的不同将其分为研究组(n=40例)和对照组(n=40例),对照组患者应用奥美拉唑、克拉霉素、胶体果胶铋和甲硝唑四种药物进行治疗,研究组患者应用雷贝拉唑、克拉霉素、胶体果胶铋和阿莫西林四种药物进行治疗,对比两组患者的治疗有效率、幽门螺杆菌根除率和治疗期间并发症发生率。结果两组患者治疗周期结束后,研究组患者的治疗有效率高于对照组(P<0.05),研究组患者的幽门螺杆菌根除率高于对照组(P<0.05),研究组患者的并发症发生率低于对照组(P<0.05)。结论在治疗HP感染引发胃溃疡的过程当中,应用雷贝拉唑、克拉霉素、胶体果胶铋和阿莫西林四种药物治疗胃溃疡效果理想,能有效根除幽门螺杆菌,并发症发生率低,临床上应当进一步推广应用。
Objective To explore the clinical efficacy of rabeprazole combined with helicobacter pylori HP in treating gastric ulcer patients with HP infection. Methods Eighty patients with gastric ulcer caused by HP infection in our hospital from 2016 to 2018 were selected as subjects of this study. All patients were treated with quadruple therapy. They were divided into intervention group ( n =40) and control group ( n = 40) according to the types of therapeutic drugs. The control group was treated with omeprazole, clarithromycin, colloidal bismuth pectin and metronidazole.The intervention group was treated with rabeprazole, clarithromycin, colloidal bismuth pectin and amoxicillin. The effective rate of treatment, eradication rate of helicobacter pylori and incidence of complications during treatment were compared between the two groups.Results At the end of the treatment cycle, the effective rate and the eradication rate of helicobacter pylori of the intervention group were both higher than the control group ( P <0.05). The incidence of complications in the intervention group was lower than the control group ( P <0.05).Conclusion In the course of treating gastric ulcer caused by HP infection, rabeprazole, clarithromycin, colloidal bismuth pectin and amoxicillin are effective in eradicating helicobacter pylori , and the incidence of complications is lower. It should be further popularized and applied in clinic.
作者
熊胜
袁曦婵
项宏溪
余文仙
XIONG Sheng;YUAN Xichan;XIANG Hongxi;YU Wenxian(Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China)
出处
《广州医药》
2019年第5期57-59,100,共4页
Guangzhou Medical Journal
关键词
胃溃疡
雷贝拉唑
抗幽门螺杆菌
四联疗法
Gastric ulcer
Rabeprazole
Anti-helicobacter pylori
Quadruple therapy
