摘要
目的:分析丙戊酸钠(VPA)对继发性癫痫患者神经元特异性烯醇化酶(NSE)和血清酸性钙结合蛋白(s-100β)水平的影响,探讨NSE和S-100β水平在VPA用药中的指导意义。方法:选择神经内科收治的继发性癫痫患者36例为观察组,给予丙戊酸钠缓释片口服治疗。在治疗前和服用药物3个月后检测血清NSE和s-100β含量。同时选择门诊健康体检者30例为对照组。结果:观察组患者血清NSE和s-100β水平均明显高于对照组,差异有统计学意义(P<0.05);观察组服用VPA3个月后,血清NSE和s-100β水平均明显降低,差异有统计学意义(P<0.05)。结论:血清NSE和s-100β水平与癫痫发作有关,且长期服用VPA能降低血清NSE和s-100β水平。
Objective:To analyze the effect of sodium valproate(VPA)on the levels of neuronspecific enolase(NSE)and serum acidic calcium binding protein(s-100β)in patients with secondary epilepsy,and to explore the guiding significance of NSE and s-100βlevels in VPA medication.Methods:All 36 patients with secondary epilepsy admitted to the Department of Neurology were treated with valproate sustained-release tablets orally.Serum NSE and s-100βlevels were measured before treatment and 3 months after treatment.At the same time,30 outpatient health examinees were selected as control.Results:The levels of serum NSE and s-100βin patients with epilepsy were significantly higher than those in healthy subjects(P<0.05).After three months of medication,the levels of serum NSE and s-100βin patients with epilepsy were significantly lower than those in healthy subjects(P<0.05).Conclusion:Serum levels of NSE and s-100βare associated with seizures,and long-term administration of VPA can reduce serum levels of NSE and s-100β.
作者
张凌云
彭慧中
杨得奖
ZHANG Lingyun;PENG Huizhong;YANG Dejiang(The Third Affiliated Hospital of Nanchang University,Nanchang 330008,China)
出处
《临床医药实践》
2019年第10期765-766,共2页
Proceeding of Clinical Medicine
