摘要
目的探讨富血小板纤维蛋白(PRF)联合引导骨再生技术(GBR)在牙周病患者颌骨缺损中精细位点重建的临床应用价值。方法选择颌骨骨量不足的牙周病患者126例,随机均分为对照组和观察组,分别给予GBR治疗和自体PRF联合GBR治疗,随访6个月。比较2组患者术后6 d修复体和牙龈情况及疼痛度,术后6个月骨缺损区骨密度及满意度。结果2组各失访2例患者,最终共纳入122例患者。2组患者术后6 d口腔黏膜瓣颜色异常率、肿胀率及疼痛度均无显著差异(P>0.05)。植入6个月后,观察组骨缺损区骨密度优的比例显著高于对照组(P<0.05),2组术后咀嚼功能以及美观度的满意度无显著差异(P>0.05)。观察组术后3、6个月修复体至牙槽嵴顶的距离显著短于对照组(P<0.05),修复体至牙槽嵴顶距离≤2 mm的比例显著高于对照组(P<0.05)。结论PRF联合GBR有利于促进牙周病颌骨缺损患者植骨治疗后骨组织修复及新生。
AIM To explore the clinical value of platelet-rich fibrin(PRF)combined with guided bone regeneration(GBR)in the reconstruction of fine sites in patients with periodontal disease and jaw defects.METHODS A total of 126 periodontal disease patients with insufficient bone mass of jaw were selected and randomized divided into control group and observation group(n=63 in each group).The control group and observation group were treated with GBR and autologous PRF combined GBR respectively,followed up for 6 months.The condition and pain of the prosthesis and gums were observed at 6 days after operation.The bone mineral density and satisfaction of the bone defect area were observed at 6 months after operation.RESULTS Two patients were lost to follow-up in each group,and a total of 122 patients were included.There were no significant differences in oral mucosal color abnormality rate,swelling rate and pain between the two groups(P>0.05).After 6 months of implantation,the excellent ratio of bone density in the bone defect area of the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in postoperative chewing function and aesthetic satisfaction between the two groups(P>0.05).The distances from the prosthesis to the alveolar crest in the observation group were significantly shorter than that in the control group at 3 and 6 months after operation(P<0.05),and the ratio of the prosthesis to the alveolar crest distance≤2 mm was significantly higher than that of the control group(P<0.05).CONCLUSION PRF combined with GBR is beneficial to promote bone tissue repair and regeneration of bone graft reatment in jaw defects patients with periodontal disease and jaw defects treatment.
作者
谢红帼
姚琴
卢骁鹏
吕敏
XIE Hong- guo;YAO Qin;LU Xiao- peng;LV Min(Department of Stomatology,Jinmen No.1 People’ s Hospital,Jinmen HUBEI 480000,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2019年第8期489-493,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
2017年度荆门市引导科研支持项目（YDKY2017016）
