摘要
目的:观察胎盘多肽注射液联合抗结核方案治疗初治菌阳肺结核的效果。方法:选取86例肺结核患者,采用随机数字表法分为观察组和对照组各43例。对照组采用2HRZE/4HR方案治疗,在对照组基础上,观察组加用胎盘多肽注射液治疗。比较两组患者的痰菌阴转率、临床疗效、T淋巴细胞亚群计数水平及不良反应发生率。结果:观察组痰菌转阴率为90.70%(39/43),明显高于对照组的72.09%(31/43),差异有统计学意义(P<0.05)。观察组治疗总有效率为95.34%,高于对照组的79.06%,差异有统计学意义(P<0.05)。治疗后,观察组CD8+水平低于对照组,CD3^+、CD4^+、CD4^+/CD8^+水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胎盘多肽注射液可提高初治菌阳肺结核患者痰菌转阴率,增强患者免疫功能,临床疗效显著。
Objective:To study effects of placental polypeptide injection combined with anti-tuberculosis regimen on newly-treated mycobacterium tuberculosis-positive pulmonary tuberculosis patients and its influence on their immune function.Methods:86 patients with pulmonary tuberculosis were selected and divided into observation group and control group according to the random number table method,43 cases in each group.The control group was treated with the 2HRZE/4HR regimen,while the observation group was treated with placental polypeptide injection based on that of the control group.The sputum negative conversion rate,efficacy,T lymphocyte subset count and adverse reaction rate were compared between the two groups.Results:The sputum negative conversion rate in the observation group was 90.70%(39/43),which was significantly higher than that in the control group(72.09%,31/43),and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 95.34%,which was higher than that of the control group(79.06%),and the difference was statistically significant(P<0.05).After the treatment,the level of CD8^+in the observation group was lower than that in the control group,and the levels of CD3^+,CD4^+and CD4^+/CD8^+were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Placental polypeptide injection can improve the sputum negative conversion rate in the patients with newly-treated mycobacterium tuberculosis-positive pulmonary tuberculosis and enhance the immune function of these patients.Therefore,it has a significant clinical effect.
作者
刘杰
LIU Jie(First Department of Tuberculosis of Jiamusi Tumor and Tuberculosis Hospital,Jiamusi 154007 Heilongjiang,China)
出处
《中国民康医学》
2019年第13期26-27,41,共3页
Medical Journal of Chinese People’s Health
关键词
胎盘多肽注射液
初治结核菌阳性肺结核
免疫功能
Placental polypeptide injection
Newly-treated mycobacterium tuberculosis-positive pulmonary tuberculosis
Immune function
