摘要
目的探讨首发精神分裂症患者血清神经调节蛋白-1(neuregulin-1,NRG-1)浓度变化及静息状态前额叶脑电图γ活动与临床症状和认知功能的相互关系。方法纳入53例首发精神分裂症患者和58名健康对照者,检测其血清NRG-1浓度,使用时频分析法采集脑电图位于前额叶FP1、FP2导联中的γ活动,采用阳性与阴性症状量表(positive and negative syndrome,PANSS)评估患者临床症状,MATRICS公认认知成套测验(MATRICS consensus cognitive battery,MCCB)进行认知功能评估。结果患者组血清NRG-1浓度低于对照组[(7.36±3.96)pg/mL vs.(11.02±8.78) pg/mL],差异有统计学意义(P=0.006)。两组间脑电图γ活动有统计学差异[39(73.6%) vs.14(26.4%),P<0.001]。MCCB测试中患者组连线测验评分高于对照组(P=0.006),符号编码、言语记忆、迷宫、视觉记忆、语义流畅性评分低于对照组(P<0.001)。患者组血清NRG-1浓度与脑电图γ活动(r=-0.542,P<0.001)、PANSS(r=-0.360,P=0.009)及言语记忆(r=0.332,P=0.016)评分相关。脑电图γ活动与PANSS(r=0.278,P=0.046)、言语记忆(r=-0.442,P=0.001)、迷宫测验(r=-0.307,P=0.027)评分分别相关。结论血清NRG-1浓度、脑电图γ活动与首发精神分裂症患者的临床症状及部分认知功能障碍有一定相关性,提示精神分裂症早期即存在神经生化及神经电生理方面的异常反应,且两者相关。
Objective To investigate the serum levels of neuregulin-1 (NRG-1) and the gamma activity of the prefrontal cortex of electroencephalogram (EEG) in the resting state in first-episode schizophrenia patients and examine their correlation with clinical symptoms and cognitive function.Methods The serum levels of NRG-1 were measured in 53 patients and 58 controls.The gamma activity was first collected from the lead of FP1 and FP2 of the prefrontal cortex of EEG and was then measured by using time-frequency analysis.The psychotic symptoms were assessed by positive and negative syndrome scale (PANSS).The MATRICS consensus cognitive battery (MCCB) was used to assess the cognitive function.Results The serum levels of NRG-1 was significantly lower in the case group than in the control [(7.36±3.96) pg/mL vs.(11.02±8.78) pg/mL,P=0.006].The gamma activity was significantly different between the case group and the control group [39(73.6%) vs.14(26.4%),P<0.001].The scores of TMT in MCCB was significantly higher while the scores of BACS SC,HVLT-R,NAB,BVMT-R and CF scores were significantly lower in the case group than the control group (P<0.01).There was a negative correlation between the serum NRG-1 level and the gamma activity in the case group (r=-0.542,P<0.001).There was a negative correlation between the serum NRG-1 level with PANSS (r=-0.360,P=0.009),while the gamma activity was positively correlated with PANSS (r=0.278,P=0.046) in the case group.The serum NRG-1 level was significantly positively correlated with the scores of HVLT-R in the case group (r=0.332,P=0.016),and the gamma activity was significantly negatively correlated with the scores of HVLT-R (r=-0.442,P=0.001) and NAB (r=-0.307,P=0.027).Conclusion The serum NRG-1 level and the gamma activity are correlated with the clinical symptoms and cognitive impairment of patients with first-episode schizophrenia to some degree,suggesting that abnormal neurobiochemical and neuroelectrophysiological reactions exist and interact with each other in the early stage of schizophrenia.
作者
李婷
康敏敏
黄正元
熊鹏
LI Ting;KANG Minmin;HUANG Zhengyuan;XIONG Peng(Department of Psychiatry,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2019年第7期390-394,共5页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金项目（编号：81360210）
云南省卫生科技计划项目基金（编号：2018NS0107）
