摘要
目的探讨益气化痰方联合多西他赛和顺铂(TP方案)对晚期非小细胞肺癌患者的临床疗效。方法 104例患者随机分为对照组和观察组,每组52例,对照组给予TP方案,观察组在对照组基础上加用益气化痰方,疗程21 d。然后,检测临床疗效、免疫功能指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、NK细胞)、血清ANGPTL2及CYFRA21-1水平、KPS评分、无进展生存期、总生存期、不良反应发生率变化。结果与对照组比较,观察组总有效率、CD3^+、CD4^+、CD4^+/CD8^+、NK细胞、KPS评分显著升高(P<0.05),CD8^+,ANGPTL2、CYFRA21-1水平,骨髓抑制、肝功能损伤发生率显著降低(P<0.05),无进展生成期显著延长(P<0.05)。结论益气化痰方联合TP方案可有效改善晚期非小细胞肺癌患者免疫损伤,提高机体免疫功能和生存质量,减少不良反应。
AIM To explore the clinical effects of Yiqi Huatan Decoction combined with docetaxel and cisplatin(TP regimen) on patients with advanced non-small cell lung cancer.METHODS One hundred and four patients were randomly divided into control group(52 cases) for 21-day TP regimen intervention, and observation group(52 cases) for 21-day Yiqi Huatan Decoction and TP regimen administration. Subsequently, the changes in clinical efficacy, immune function indices(CD3^+, CD4^+, CD8^+, CD4^+/CD8^+, NK cell), serum ANGPTL2 and CYFRA21-1 levels, KPS score, progression-free survival, overall survival and occurrence rate of adverse reactions were detected.RESULTS Compared with the control group, the observation group demonstrated significantly increased total effective rate, CD3^+, CD4^+, CD4^+/CD8^+, NK cell, KPS score(P<0.05), markedly decreased CD8^+, ANGPTL2 and CYFRA21-1 levels, occurance rates of bone marrow inhibition and liver function impairment(P<0.05), and obviously prolonged progression-free survival(P<0.05).CONCLUSION For the patients with advanced non-small cell lung cancer, Yiqi Huatan Decoction combined with TP regimen can effectively improve immune damage, enhance body immune functions and life quality, and reduce adverse reactions.
作者
曹世霞
康斐
王永飞
杜艳平
CAO Shi-xia;KANG Fei;WANG Yong-fei;DU Yan-ping(Zhengzhou University of Industrial Technology,Xinzheng 451100,China;The Third Hospital Affiliated to Henan University of Chinese Medicine,Zhengzhou 450000,China;People’s Hospital of Xinzheng,Xinzheng 451100,China)
出处
《中成药》
CAS
CSCD
北大核心
2019年第8期1835-1839,共5页
Chinese Traditional Patent Medicine
关键词
益气化痰方
TP方案
晚期非小细胞肺癌
Yiqi Huatan Decoction
TP regimen
advanced non-small cell lung cancer
